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Pyrosequencing evaluation of low-frequency KRAS mutant alleles for EGF recept...

Natalicchio(Maria Iole),Improta(Giuseppina... Future Oncol 2014-12-22

...PIK3CA mutations mostly in KRAS wild-type mCRCs resistant to EGFR therapy.,PS detection of low-frequency mutations may i...

Serum levels of hepatocyte growth factor and epiregulin are associated with t...

Takahashi(N),Yamada(Y),Furuta(K),Honma(Y),... Br J Cancer 2014-07-14

...PIK3CA and BRAF were analysed by direct sequencing.,A total of 103 patients were enrolled in the present study. At the p...

Molecular patterns in deficient mismatch repair colorectal tumours: results f...

Etienne-Grimaldi(M-C),Mahamat(A),Chazal(M)... Br J Cancer 2014-07-14

...PIK3CA (exons 9 and 20), APC (exon 15) and P53 (exons 4-9), CpG island methylation phenotype status, ploidy, S-phase, LO...

Molecular profiling of appendiceal epithelial tumors using massively parallel...

Liu(Xiaoying),Mody(Kabir),de Abreu(Francin... Clin Chem 2014-08-14

...PIK3CA), RB1 (retinoblastoma 1), STK11 (serine/threonine kinase 11), and tumor protein p53 (TP53) genes. Among the PMPs,...

Molecular genetics of clear-cell renal cell carcinoma.

Brugarolas(James) J Clin Oncol 2014-08-04

...PIK3CA, and PTEN in approximately 20% of ccRCCs. Mutations in TSC1, and possibly other genes, may predict for sensitivit...

Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in...

Guo(Shang),Lopez-Marquez(Hector),Fan(Kenne... PLoS One 2014-11-17

...PIK3CA gene in 4 of 18 human liposarcoma patients (22%). No PIK3CA mutations were identified in benign lipomas. Western ...

Multigene profiling to identify alternative treatment options for glioblastom...

Tabone(Tania),Abuhusain(Hazem J),Nowak(Ann... J Clin Pathol 2014-08-15

...PIK3CA (n=5). Clinically actionable somatic mutations were detected in 24/35 (69%) patients.,This study demonstrates tha...

Multicenter phase II study of second-line cetuximab plus folinic acid/5-fluor...

Iwamoto(Shigeyoshi),Hazama(Shoichi),Kato(T... Anticancer Res 2014-06-15

...PIK3CA genotyping.,Tumors of 112 pre-registered patients were genotyped for KRAS, BRAF, and PIK3CA. The primary study en...

Assessment of mutational profile of Japanese lung adenocarcinoma patients by ...

Serizawa(Masakuni),Koh(Yasuhiro),Kenmotsu(... Cancer 2014-06-16

...PIK3CA, NRAS, MEK1, AKT1, PTEN, and HER2), gene amplifications in 5 genes (EGFR, MET, PIK3CA, FGFR1, and FGFR2), and ALK...

Late onset epidermal nevus with hypertrichosis and facial hemihypertrophy.

Saritha(M),Chandrashekar(Laxmisha),Thappa(... Indian J Dermatol 2014-04-04

...PIK3CA mutations. The patient has features that cannot be categorized into the present well-known syndromes.

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