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TP53 BRCA1 CRISPR single-cell cancer

Saleh(Anthony D),Simone(Brittany A),Palazz... Cell Cycle 2014-02-04

...PIK3ca and mTOR were found to be downregulated. The innovative use of CR as a novel therapeutic option has the potential...

Deming(D A),Leystra(A A),Nettekoven(L),Sie... Oncogene 2014-06-10

...PIK3CA mutations, we sought to better understand the interaction between APC and PIK3CA mutations in the mammalian intes...

Trigka(Eleni Andriana),Levidou(Georgia),Sa... Oncol Rep 2014-02-27

...PIK3CA, AKT1, PTEN and K-RAS mutations. A common PIK3CA mutation was detected at exon 9 in 2 samples (p.E545K), whereas ...

Bosse(Tjalling),ter Haar(Natalja T),Seeber... Mod Pathol 2014-06-23

...PIK3CA mutations), TP53 status (TP53 immunohistochemistry) and microsatellite instability. To discriminate between micro...

Ikeda(Yuji),Oda(Katsutoshi),Hiraike-Wada(O... Oncol Rep 2014-02-27

...PIK3CA and/or PTEN and showed accumulation of cyclin D1 in the nucleus by immunohistochemistry. Furthermore, we analyzed...

Markowska(Anna),Pawałowska(Monika),Lubin(J... Contemp Oncol (Pozn) 2014-12-18

...PIK3CA or Akt result in increased transmission in the PI3K/Akt pathway, apoptosis inhibition, intensive cell division, m...

Kim(Hye Ryun),Cho(Byoung Chul),Shim(Hyo Su... Lung Cancer 2014-10-10

...PIK3CA, PTEN, AKT and STK11, which are all EGFR-downstream genes. Mutations in PIK3CA, PTEN, AKT, and STK11 were analyze...

Ebi(Hiromichi),Costa(Carlotta),Faber(Antho... Proc Natl Acad Sci U S A 2014-02-27

The PI3K pathway is genetically altered in excess of 70% of breast cancers, largely through PIK3CA mutation and HER2 amp...

Zhao(Qiu),Zhang(Bin),Shao(Yongfeng),Chen(L... Future Oncol 2014-08-27

...PIK3CA expression (p < 0.05). Patients with low miR-1 expression and those with high PIK3CA expression had significantly...

Black(Jonathan D),English(Diana P),Roque(D... Womens Health (Lond) 2014-08-28

...PIK3CA/AKT/mTOR and cyclin E/FBXW7 oncogenic pathways in a large number of USCs. These results emphasize the relevance o...

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