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Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous...

Schwab(Richard),Petak(Istvan),Kollar(Mihal... Lung Cancer 2014-10-01

...PIK3CA genes were wild type, ALK and ROS1 were negative for rearrangement, but c-MET was amplified by fluorescent in sit...

Frequent PIK3CA mutations in radial scars.

Wolters(Katie L),Ang(Daphne),Warrick(Andre... Diagn Mol Pathol 2014-06-26

...PIK3CA are found in 25% to 30% of invasive breast cancers; however, they have not previously been investigated in radial...

Role of the PI3K/AKT pathway in modulating cytoskeleton rearrangements and ph...

Fan(Zhiyu),Li(Chunyu),Qin(Chaoyi),Xie(Lian... DNA Cell Biol 2014-03-03

...PIK3CA-adenovirus induced cytoskeleton rearrangements and downregulated SM22α and α-SM actin gene expression. Inhibition...

Invited review DNA copy number changes as diagnostic tools for lung cancer.

Bowcock(Anne M) Thorax 2014-05-27

...PIK3CA gene and evaluation of the number of copies of this gene gave very similar results to those from array comparativ...

Targeting small cell lung cancer harboring PIK3CA mutation with a selective o...

Walls(Marlena),Baxi(Sangita M),Mehta(Pramo... Clin Cancer Res 2014-10-06

...PIK3CA mutation.,A panel of SCLC cell lines with PIK3CA mutation or PTEN loss were treated with PF-4989216 in several in...

PIK3CA hypomethylation plays a key role in activation of the PI3K/AKT pathway...

Wang(Wei-feng),Xie(Yan),Zhou(Zhi-hua),Qin(... Acta Pharmacol Sin 2014-05-29

...PIK3CA gene were detected using conventional sequencing. PIK3CA methylation rates in two selected CpG islands (CpG islan...

Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas.

Joseph(Christine G),Hwang(Heejung),Jiao(Yu... Genes Chromosomes Cancer 2014-03-19

...PIK3CA, SETD2, AKT1, and subclonal mutation in FBXW7. Of particular interest were mutations in H3F3A, encoding the varia...

High throughput molecular profiling reveals differential mutation patterns in...

Jang(Sejin),Chun(Sung-Min),Hong(Seoung-Mo)... Mod Pathol 2014-12-24

...PIK3CA, CDKN2A, PTEN, and TP53 mutations were found with less than 5%. Overall mutation rate of intrahepatic cholangioca...

Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesi...

Ang(Daphne C),Warrick(Andrea L),Shilling(A... Mod Pathol 2014-12-24

...PIK3CA substitutions. PIK3CA point mutations were identified in 31/62 (50%) proliferative lesions (usual ductal hyperpla...

Epidermal growth factor receptor signaling pathway is frequently altered in a...

Mikhitarian(Kaidi),Pollen(Maressa),Zhao(Zh... Mod Pathol 2014-12-24

...PIK3CA, PTEN, and AKT1. A total of 52 ampullary carcinomas were identified, including 25 intestinal-type and 24 pancreat...

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