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Mutational analysis and clinical correlation of metastatic colorectal cancer.

Russo(Andrea L),Borger(Darrell R),Szymonifka… Cancer 2014-06-16

...PIK3CA mutations (23% vs 8.7%; P = .004). Only mutations in BRAF were independently associated with decreased overall su...

PIK3CA mutation predicts resistance to breast cancer therapy.

Cancer Discov 2014-09-30

...PIK3CA were less likely to benefit from neoadjuvant chemotherapy and HER2-targeted therapies than those without a mutati...

Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis …

Yoon(Heejei),Choi(Yoon-La),Song(Ji-Young),Do… PLoS One 2014-10-28

...PIK3CA accounted for about 40% of OCCC samples, suggesting that the FAK/PI3K/AKT axis is an attractive candidate for tar...

MicroRNA-10a controls airway smooth muscle cell proliferation via direct target…

Hu(Ruoxi),Pan(Wenchi),Fedulov(Alexey V),Jest… FASEB J 2014-06-16

...PIK3CA), the central component of the PI3K pathway. MiR-10a directly suppresses PIK3CA expression by targeting the 3'-un...

Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isofo…

Gritsman(Kira),Yuzugullu(Haluk),Von(Thanh),Y… J Clin Invest 2014-06-02

...Pik3ca) is an essential effector of oncogenic KRAS in murine lung tumors, but it is unknown whether p110α contributes to...

Targeted therapies in development for non-small cell lung cancer.

Reungwetwattana(Thanyanan),Dy(Grace Kho) J Carcinog 2014-06-24

...PIK3CA (phosphatidylinositol-4,5-bisphosphate3-kinase, catalytic subunit alpha)), PTEN (phosphatase and tensin homolog),...

Assessment of mutational profile of Japanese lung adenocarcinoma patients by mu…

Serizawa(Masakuni),Koh(Yasuhiro),Kenmotsu(Hi… Cancer 2014-06-16

...PIK3CA, NRAS, MEK1, AKT1, PTEN, and HER2), gene amplifications in 5 genes (EGFR, MET, PIK3CA, FGFR1, and FGFR2), and ALK...

Late onset epidermal nevus with hypertrichosis and facial hemihypertrophy.

Saritha(M),Chandrashekar(Laxmisha),Thappa(De… Indian J Dermatol 2014-04-04

...PIK3CA mutations. The patient has features that cannot be categorized into the present well-known syndromes.

Anti-epidermal growth factor receptor monoclonal antibody-based therapy for met…

Huang(Lulu),Liu(Zhenfang),Deng(Donghong),Tan… Arch Med Sci 2014-06-24

We conducted a meta-analysis to dissect the association between PIK3CA mutations (exon 9 and exon 20) and resistance to ...

Assessing the efficacy of targeting the phosphatidylinositol 3-kinase/AKT/mTOR …

Bradford(Leslie S),Rauh-Hain(Alejandro),Clar… Gynecol Oncol 2014-06-12

...PIK3CA mutation was observed. Acute treatment with BKM led to a decrease in pAKT levels.,Independent of PIK3CA gene muta...

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