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Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in l…

Guo(Shang),Lopez-Marquez(Hector),Fan(Kenneth… PLoS One 2014-11-17

...PIK3CA gene in 4 of 18 human liposarcoma patients (22%). No PIK3CA mutations were identified in benign lipomas. Western ...

Multigene profiling to identify alternative treatment options for glioblastoma:…

Tabone(Tania),Abuhusain(Hazem J),Nowak(Anna … J Clin Pathol 2014-08-15

...PIK3CA (n=5). Clinically actionable somatic mutations were detected in 24/35 (69%) patients.,This study demonstrates tha...

Genetic mechanisms in interval colon cancers.

Richter(James M),Pino(Maria Simona),Austin(T… Dig Dis Sci 2014-10-17

...PIK3CA oncogenes was similar between interval cancer cases and controls.,Interval colon cancers are not distinguished by...

Defined morphological criteria allow reliable diagnosis of colorectal serrated …

Rau(Tilman T),Agaimy(Abbas),Gehoff(Anastasia… Virchows Arch 2014-07-29

...PIK3CA and the methylation status of MLH1. Gender, age and localisation were significantly associated with certain types...

Primary concomitant EGFR T790M mutation predicted worse prognosis in non-small …

Li(Hang),Hu(Haichuan),Wang(Rui),Pan(Yunjian)… Onco Targets Ther 2014-04-14

...PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha), and EML4 (echinoderm microtubule assoc...

Immunohistochemical analysis of PDK1 expression in breast cancer.

Arsenic(Ruza) Diagn Pathol 2014-12-30

...PIK3CA mutation status.,Moderate or high expression of PDK1 was observed in 213 of the 241 cases (88%). There was no cor...

A GG allele of 3'-side AKT1 SNP is associated with decreased AKT1 activation an…

Wang(Xiaoting),Lin(Youdong),Lan(Fenghua),Yu(… J Cancer Res Clin Oncol 2014-09-02

...PIK3CA, PTEN, AKT1, and mTOR, were determined in 221 patients with stage T2 and T3 gastric cancer. Additionally, the act...

BRAF mutation predicts for poor outcomes after metastasectomy in patients with …

Yaeger(Rona),Cercek(Andrea),Chou(Joanne F),S… Cancer 2014-12-09

...PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) mutation frequency, and outcomes after ...

De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalenceph…

Mirzaa(Ghayda M),Parry(David A),Fry(Andrew E… Nat Genet 2014-06-16

...PIK3CA, PIK3R2 or AKT3 mutations showed similar CCND2 accumulation. CCND2 was expressed at higher levels in brains of mo...

PIK3CA mutations in mucinous cystic neoplasms of the pancreas.

Garcia-Carracedo(Dario),Chen(Zong-Ming),Qiu(… Pancreas 2014-10-20

...PIK3CA gene and the E17K mutation in the AKT1 gene.,A hot-spot mutation (E545K) of the PIK3CA gene was detected in 1 of ...

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