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Somatic profiling of the epidermal growth factor receptor pathway in tumors f...

Smith(Christopher G),Fisher(David),Claes(B... Clin Cancer Res 2014-03-17

...PIK3CA mutations in 12.7%. 4.2% of advanced colorectal cancers had microsatellite instability (MSI). KRAS and PIK3CA exo...

Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterati...

Bosse(Tjalling),ter Haar(Natalja T),Seeber... Mod Pathol 2014-06-23

...PIK3CA mutations), TP53 status (TP53 immunohistochemistry) and microsatellite instability. To discriminate between micro...

Caloric restriction augments radiation efficacy in breast cancer.

Saleh(Anthony D),Simone(Brittany A),Palazz... Cell Cycle 2014-02-04

...PIK3ca and mTOR were found to be downregulated. The innovative use of CR as a novel therapeutic option has the potential...

PIK3CA and APC mutations are synergistic in the development of intestinal can...

Deming(D A),Leystra(A A),Nettekoven(L),Sie... Oncogene 2014-06-10

...PIK3CA mutations, we sought to better understand the interaction between APC and PIK3CA mutations in the mammalian intes...

Overexpression of hypoxia inducible factor-1 alpha is an independent risk fac...

Shimomura(Manabu),Hinoi(Takao),Kuroda(Shin... Ann Surg Oncol 2014-08-28

...PIK3CA). Finally, we compared HIF-1α expression between the primary tumor and the corresponding liver metastases.,We fou...

Identification of anaplastic lymphoma kinase break points and oncogenic mutat...

Niu(Hai-Tao),Zhou(Qi-Ming),Wang(Fang),Shao... Pigment Cell Melanoma Res 2014-05-05

...PIK3CA mutation. Two cases exhibited co-occurring mutations, and one case with a BRAF mutation had a translocation in AL...

Descriptive profile of PIK3CA-mutated colorectal cancer in postmenopausal women.

Phipps(Amanda I),Makar(Karen W),Newcomb(Po... Int J Colorectal Dis 2014-06-18

...PIK3CA). We evaluated the relationship between PIK3CA mutation status and demographic factors, lifestyle factors, and ot...

Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endom...

Ikeda(Yuji),Oda(Katsutoshi),Hiraike-Wada(O... Oncol Rep 2014-02-27

...PIK3CA and/or PTEN and showed accumulation of cyclin D1 in the nucleus by immunohistochemistry. Furthermore, we analyzed...

Clinical perspective of afatinib in non-small cell lung cancer.

Chen(Xiaofeng),Zhu(Quan),Zhu(Lingjun),Pei(... Lung Cancer 2014-05-01

...PIK3CA gene mutation, transdifferentiation into small-cell lung cancer and additional rare or unkown mechanisms. Afatini...

A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung ...

Trigka(Eleni Andriana),Levidou(Georgia),Sa... Oncol Rep 2014-02-27

...PIK3CA, AKT1, PTEN and K-RAS mutations. A common PIK3CA mutation was detected at exon 9 in 2 samples (p.E545K), whereas ...

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