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Emerging protein kinase inhibitors for non-small cell lung cancer.

Liu(Stephen V),Subramaniam(Deepa),Cyriac(G... Expert Opin Emerg Drugs 2014-10-06

...PIK3CA, FGFR1, DDR2, VEGFR and AAK.,In EGFR-mutant NSCLC, there are several kinase inhibitors with promising activity, m...

Targeted next-generation sequencing panel (ThyroSeq) for detection of mutatio...

Nikiforova(Marina N),Wald(Abigail I),Roy(S... J Clin Endocrinol Metab 2014-01-02

...PIK3CA, TP53, TSHR, PTEN, GNAS, CTNNB1, and RET. The BRAF mutant allele frequency was 18%-48% in PTCs and was lower in A...

[Association of epithermal growth factor receptor expression and its downstre...

Zuo(Zhi-gui),Yu(Zhi-qi),Gao(Xian-hua),Wang... Zhonghua Wei Chang Wai Ke Z... 2014-03-20

To investigate the effect of epithermal growth factor receptor (EGFR) expression and K-ras, B-raf and PIK3CA mutation st...

Prognostic significance of MTOR pathway component expression in neuroendocrin...

Qian(Zhi Rong),Ter-Minassian(Monica),Chan(... J Clin Oncol 2014-05-05

...PIK3CA, MTOR, or p-EIF4EBP1 was associated with high MKI67 (Ki-67) labeling index. We failed to identify clinical correl...

PIK3CA hypomethylation plays a key role in activation of the PI3K/AKT pathway...

Wang(Wei-feng),Xie(Yan),Zhou(Zhi-hua),Qin(... Acta Pharmacol Sin 2014-05-29

...PIK3CA gene were detected using conventional sequencing. PIK3CA methylation rates in two selected CpG islands (CpG islan...

PIK3R1 underexpression is an independent prognostic marker in breast cancer.

Cizkova(Magdalena),Vacher(Sophie),Meseure(... BMC Cancer 2014-06-23

...PIK3CA mutations (p = 0.00097). PIK3CA mutations were associated with better metastasis-free survival and PIK3R1 underex...

EGFR gene gain and PTEN protein expression are favorable prognostic factors i...

Razis(Evangelia),Pentheroudakis(George),Ri... J Cancer Res Clin Oncol 2014-06-04

...PIK3CA, BRAF and KRAS mutation status and EGFR ligand amphiregulin (AREG) and epiregulin intratumoral mRNA expression le...

[Perspective of personalized (precise) cancer therapy based on predictive bio...

Osera(Shozo),Yoshino(Takayuki) Nihon Rinsho 2014-03-20

...PIK3CA for anti-EGFR monoclonal antibody, and pVEGF-A for bevacizumab have been reported. We review the biomarkers assoc...

Oncogene mutational profile in nasopharyngeal carcinoma.

Zhang(Zi-Chen),Fu(Sha),Wang(Fang),Wang(Hai... Onco Targets Ther 2014-03-27

...PIK3CA mutations (4.9%), five NRAS mutations (4.1%), four KIT mutations (3.3%), two PDGFRA mutations (1.6%), two ABL mut...

Identification of genomic alterations in oesophageal squamous cell cancer.

Song(Yongmei),Li(Lin),Ou(Yunwei),Gao(Zhibo... Nature 2014-06-16

...PIK3CA, NOTCH1, NFE2L2), and two have not previously been described in ESCC (ADAM29 and FAM135B). Notably, FAM135B is id...

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