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Towards the goal of personalized medicine in gastric cancer--time to move bey...

Lee(Jeeyun),Ou(Sai-Hong Ignatius) Discov Med 2014-02-18

...PIK3CA, BRAF) and gene rearrangement (ROS1, BRAF, HER2). Because of the low frequency of these potential driver mutation...

mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK...

Elkabets(Moshe),Vora(Sadhna),Juric(Dejan),... Sci Transl Med 2014-05-08

Activating mutations of the PIK3CA gene occur frequently in breast cancer, and inhibitors that are specific for phosphat...

CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma.

Matsuura(Shun),Shinmura(Kazuya),Kamo(Takah... Oncol Rep 2014-04-29

...PIK3CA genes and the entire coding region of p53 in the carcinoma, and the expression of ALK fusion was negative. The ab...

Identification of multiple mechanisms of resistance to vemurafenib in a patie...

Romano(Emanuela),Pradervand(Sylvain),Paill... Clin Cancer Res 2014-05-19

...PIK3CA(H1047R) mutation was detected in a subpopulation of PV1, but this mutation did not seem to play a major role in v...

Loss of PTEN expression is an independent predictor of favourable survival in...

Akiyama-Abe(A),Minaguchi(T),Nakamura(Y),Mi... Br J Cancer 2014-05-05

...PIK3CA was overexpressed in 159 patients (72%). Overexpression of PIK3CA was associated with p-Akt overexpression (P<0.0...

Pattern of clinically relevant mutations in consecutive series of Russian col...

Yanus(Grigoriy A),Belyaeva(Anna V),Ivantso... Med Oncol 2014-04-17

...PIK3CA genes as well as for the microsatellite instability status. Comparison between high-resolution melting analysis, ...

Next-generation sequencing-based multi-gene mutation profiling of solid tumor...

Kanagal-Shamanna(Rashmi),Portier(Bryce P),... Mod Pathol 2014-09-24

...PIK3CA, RET and TP53, deletions of EGFR and wild-type calls. Furthermore, next-generation sequencing detected variants i...

Phase I study of everolimus and mitomycin C for patients with metastatic esop...

Werner(Dominique),Atmaca(Akin),Pauligk(Cla... Cancer Med 2014-04-15

...PIK3CA, AKT1, CTNNB1, and E-cadherin type 1 genes. Sixteen patients (12 male, four female) with gastric/gastroesophageal...

Analysis of PIK3CA exon 9 and 20 mutations in breast cancers using PCR-HRM an...

Harlé(Alexandre),Lion(Maëva),Lozano(Nicola... Oncol Rep 2014-04-11

...PIK3CA oncogene, is mutated in 18-45% of breast carcinomas. These mutations, involved in tumorigenic process...

Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multic...

Arcaroli(John),Quackenbush(Kevin),Dasari(A... Cancer Med 2014-01-27

...PIK3CA mutant) based on preclinical data in a human pancreas tumor explant model. In the biomarker study, archival tumor...

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