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TP53 BRCA1 CRISPR single-cell cancer

Wiesweg(Marcel),Ting(Saskia),Reis(Henning)... Eur J Cancer 2014-05-06

...PIK3CA mutations was extremely low. In pulmonary squamous cell carcinoma FGFR1 amplifications were found in 15%, PTEN ex...

Anderson(Ryan T),Keysar(Stephen B),Bowles(... Mol Cancer Ther 2014-05-19

...PIK3CA alterations in squamous cell carcinoma of the head and neck (HNSCC) has raised interest in exploring agents targe...

Lee(Jeeyun),Ou(Sai-Hong Ignatius) Discov Med 2014-02-18

...PIK3CA, BRAF) and gene rearrangement (ROS1, BRAF, HER2). Because of the low frequency of these potential driver mutation...

English(Diana P),Bellone(Stefania),Cocco(E... Am J Obstet Gynecol 2014-01-06

To evaluate PIK3CA mutational status and c-erbB2 gene amplification in a series of primary uterine serous carcinomas (US...

Elkabets(Moshe),Vora(Sadhna),Juric(Dejan),... Sci Transl Med 2014-05-08

Activating mutations of the PIK3CA gene occur frequently in breast cancer, and inhibitors that are specific for phosphat...

Deb(Siddhartha),Do(Hongdo),Byrne(David),Je... Breast Cancer Res 2014-12-08

...PIK3CA/mTOR pathway was performed using immunohistochemistry for the pAKT1, pS6 and p4EBP1 biomarkers.,PIK3CA somatic mu...

Matsuura(Shun),Shinmura(Kazuya),Kamo(Takah... Oncol Rep 2014-04-29

...PIK3CA genes and the entire coding region of p53 in the carcinoma, and the expression of ALK fusion was negative. The ab...

Ross(Jeffrey S),Wang(Kai),Al-Rohil(Rami N)... Mod Pathol 2014-09-24

...PIK3CA (9 cases; 26%); CDKN2A/B (8 cases; 23%); CCND1 (5 cases; 14%); FGFR1 (5 cases; 14%); CCND3 (4 cases; 11%); FGFR3 ...

Kuhn(Elisabetta),Ayhan(Ayse),Shih(Ie-Ming)... Mod Pathol 2014-09-24

...PIK3CA somatic mutations were detected in the stromal component in 1 (5%) of 20 Brenner tumors and 3 somatic mutations (...

Beaver(Julia A),Gustin(John P),Yi(Kyung H)... Clin Cancer Res 2014-05-08

...PIK3CA wild-type background restored pathway signaling, proliferation, and tumor growth in vivo. PIK3CA, but not AKT1 mu...

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