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PIK3CA activating mutation in colorectal carcinoma: associations with molecul...

Rosty(Christophe),Young(Joanne P),Walsh(Mi... PLoS One 2014-01-21

...PIK3CA are present in 10 to 15% of colorectal carcinomas. We aimed to examine how PIK3CA mutations relate to other molec...

Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of th...

Chang(Kwang-Yu),Tsai(Shan-Yin),Chen(Shang-... J Biomed Sci 2014-02-13

...PIK3CA revealed that 24.8% of the samples had alterations, and of EGFR showed that 49.0% had amplification. Direct seque...

Lung adenocarcinoma biomarker incidence in Hispanic versus non-Hispanic white...

McQuitty(Elizabeth),Zhang(Wei),Hendrickson... Arch Pathol Lab Med 2014-05-01

...PIK3CA, AKT1 through AKT3, and PTEN with a custom Sequenom massARRAY assay (Sequenom, San Diego, California).,Mutations ...

Reconstruction of an integrated genome-scale co-expression network reveals ke...

Bidkhori(Gholamreza),Narimani(Zahra),Hosse... PLoS One 2014-04-17

...PIK3CA, TAF15, XIAP, VAPB, Appl1, Rab5a, ARF4, CLPTM1L, SP4, ZNF124, LPP, FOXP1, SOX18, MSX2, NFE2L2, SMARCC1, TRA2B, CB...

Bevacizumab confers additional advantage to the combination of trastuzumab pl...

Sun(Yuliang),Dey(Nandini),Brammer(Melissa)... Cancer Chemother Pharmacol 2014-04-28

...PIK3CA mutated (HCC1954) BT cell lines by 3D ON-TOP clonogenic growth assay and Western blots.,Data show (1) T, T-DM1 or...

Morphological change of a laterally spreading rectal tumor over a short perio...

Miyamoto(Hideaki),Oono(Yasuhiro),Fu(Kuang-... BMC Gastroenterol 2014-04-01

...PIK3CA genes in flat part and nodular part separately, and a mutation of KRAS gene at codon 146 was observed at only nod...

Phosphatidylinositol-3-kinase pathway aberrations in gastric and colorectal c...

Chong(Mei-Ling),Loh(Marie),Thakkar(Bhavin)... Int J Cancer 2014-02-12

...PIK3CA mutation, PIK3CA amplification and PTEN deletion) and protein expression (high PI3K, PTEN loss and high pAkt) abe...

Preclinical evaluation of the PI3K-mTOR dual inhibitor PF-04691502 as a novel...

Wong(Chi Hang),Loong(Herbert H),Hui(Connie... Invest New Drugs 2014-07-08

...PIK3CA amplification. This study characterized the preclinical activity of a novel potent dual PI3K/mTOR inhibitor, PF-0...

Biology and therapeutic potential of PI3K signaling in ER+/HER2-negative brea...

Fu(Xiaoyong),Osborne(C Kent),Schiff(Rachel... Breast 2014-05-29

...PIK3CA mutations mostly found in the luminal subtypes of BC. The transcriptomic and proteomic signatures of PI3K pathway...

Driver mutations among never smoking female lung cancer tissues in China iden...

Hosgood(H Dean),Pao(William),Rothman(Natha... Respir Med 2014-06-10

...PIK3CA, MEK1, AKT1, and PTEN) among the lung tumors of confirmed never smoking females from Xuanwei, China [32 adenocarc...

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