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Activating PIK3CA alleles and lymphangiogenic phenotype of lymphatic endothel...

Osborn(Alexander J),Dickie(Peter),Neilson(... Hum Mol Genet 2015-09-22

...PIK3CA (p.H1047L), confirmed by direct sequencing. Activating PIK3CA mutations (p.E542K and p.E545A) were identified in ...

Next generation MUT-MAP, a high-sensitivity high-throughput microfluidics chi...

Schleifman(Erica B),Tam(Rachel),Patel(Raje... PLoS One 2015-01-16

...PIK3CA) using allele-specific PCR (AS-PCR) and Taqman technology. This mutation panel requires as little as 2 ng of high...

PI3K pathway activation in high-grade ductal carcinoma in situ--implications ...

Sakr(Rita A),Weigelt(Britta),Chandarlapaty... Clin Cancer Res 2015-08-20

...PIK3CA-mutant allelic frequencies in DCIS and synchronous IBC revealed cases in which PIK3CA mutations were either restr...

Effect of aromatase inhibition on functional gene modules in estrogen recepto...

Gao(Qiong),Patani(Neill),Dunbier(Anita K),... Clin Cancer Res 2015-08-20

...PIK3CA modules. Modules measuring estrogen signaling strongly predicted antiproliferative response to therapy with and w...

Segmental overgrowth syndrome due to an activating PIK3CA mutation identified...

Rasmussen(Maria),Sunde(Lone),Weigert(Karen... Am J Med Genet A 2015-08-19

Mosaic PIK3CA-mutations have been described in an increasing number of overgrowth syndromes. We describe a patient with ...

The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treat...

Therkildsen(Christina),Bergmann(Troels K),... Acta Oncol 2015-10-19

...PIK3CA and PTEN in relation to the clinical benefit from anti-EGFR treatment.,In total, 22 studies that include 2395 pat...

Profiling cancer gene mutations in clinical formalin-fixed, paraffin-embedded...

Zhang(Liangxuan),Chen(Liangjing),Sah(Sachi... Oncologist 2015-01-12

...PIK3CA.,AmpliSeq provided highly sensitive and quantitative mutation detection for most of the genes on its cancer panel...

Activity of abiraterone in rechallenging two AR-expressing salivary gland ade...

Locati(Laura D),Perrone(Federica),Cortelaz... Cancer Biol Ther 2015-01-22

...PIK3CA-activating mutation in the other. In conclusion, second line activity of ADT in AR-expressing, adenocarcinoma, NO...

Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral ...

Rodon(Jordi),Braña(Irene),Siu(Lillian L),D... Invest New Drugs 2015-03-02

...PIK3CA and/or PTEN alterations.,The most common cancers were colorectal (n = 31) and breast cancer (n = 21). Median numb...

Integrated analysis of cancer-related pathways affected by genetic and epigen...

Yoda(Yukie),Takeshima(Hideyuki),Niwa(Tohru... Gastric Cancer 2015-08-06

...PIK3CA and PTPN11 in 4 GCs. The MAPK pathway was activated by mutations and gene amplifications of ERBB2, FLT3, and KRAS...

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