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Comparison of neuroendocrine differentiation and KRAS/NRAS/BRAF/PIK3CA/TP53 m...

Kleist(Britta),Kempa(Marcel),Novy(Michael)... Int J Clin Exp Pathol 2015-07-02

...PIK3CA/TP53 mutational status in primary and metastatic CRC. Immunohistochemical expression analysis of neuroendocrine m...

Outcomes of patients with advanced cancer and KRAS mutations in phase I clini...

Said(Rabih),Ye(Yang),Falchook(Gerald Steve... Oncotarget 2015-08-07

...PIK3CA mutations were found in 24% and 10% of patients with and without KRAS mutations (p<0.0001). Of 223 patients with ...

Biological and molecular effects of small molecule kinase inhibitors on low-p...

Lange(Falko),Franz(Benjamin),Maletzki(Clau... Biomed Res Int 2015-07-02

...PIK3CA, and TP53 mutations. Regorafenib action was associated with broad-range inhibitory effects at the level of gene e...

PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis...

Wu(Chia-Yen C),Carpenter(Eileen S),Takeuch... Gastroenterology 2015-02-04

...Pik3ca), p110β (Pik3cb), or RAC1 (Rac1). Pancreatitis was induced with 5 daily intraperitoneal injections of cerulein. P...

Nanoplasmonic biosensor: detection and amplification of dual bio-signatures o...

Nguyen(Anh H),Sim(Sang Jun) Biosens Bioelectron 2015-11-06

...PIK3CA gene based on localized surface plasmon resonance (LSPR) and the coupling plasmon mode of gold nanoparticles (AuN...

Targeted genomic analysis of Müllerian adenosarcoma.

Howitt(Brooke E),Sholl(Lynette M),Dal Cin(... J Pathol 2015-03-11

...PIK3CA/AKT/PTEN pathway members were seen in 13/18 (72%). Notably, TP53 mutations were uncommon, present in only two cas...

First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying t...

Blagden(Sarah),Omlin(Aurelius),Olmin(Aurel... Clin Cancer Res 2015-07-28

...PIK3CA-mutated clear cell carcinoma of the ovary achieved a partial response by GCIG CA125 criteria and further, a heavi...

Mutational profiling of kinases in glioblastoma.

Bleeker(Fonnet E),Lamba(Simona),Zanon(Carl... BMC Cancer 2015-06-01

...PIK3CA, EGFR, BRAF, EPHA3, NRAS, TGFBR2, FLT3 and RPS6KC1. Mapping the mutated genes into known signaling pathways revea...

Identification of novel mutations by exome sequencing in African American col...

Ashktorab(Hassan),Daremipouran(Mohammad),D... Cancer 2015-02-25

...PIK3CA. We detected novel alterations in the Wnt pathway gene, APC, within its exon 15, of which mutations are highly as...

Tongue carcinoma infrequently harbor common actionable genetic alterations.

Tan(Daniel S W),Wang(Weining),Leong(Hui Su... BMC Cancer 2015-05-28

...PIK3CA, BRAF and NRF2. No activating EGFR mutations or KRAS mutations were discovered in our series, where just over a t...

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