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First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I p...

Sarker(Debashis),Ang(Joo Ern),Baird(Richar... Clin Cancer Res 2015-09-21

...PIK3CA amplification demonstrated partial response by RECIST and GCIG-CA125 criteria, respectively.,Pictilisib was safel...

PIK3CA mutational status in circulating tumor cells can change during disease...

Markou(Athina),Farkona(Sofia),Schiza(Chris... Clin Cancer Res 2015-07-09

...PIK3CA somatic mutations play a crucial role in therapy response. We investigated the presence of PIK3CA mutations in CT...

Phase II clinical and exploratory biomarker study of dacomitinib in patients ...

Kim(Han Sang),Kwon(Hyeong Ju),Jung(Inkyung... Clin Cancer Res 2015-09-22

...PIK3CA, PTEN) and high expression of inflammatory cytokines (IL6, IL8, IL1A, IL1B, IL4, and TNF) were significantly asso...

Exploiting high-throughput cell line drug screening studies to identify candi...

Nichols(Anthony C),Black(Morgan),Yoo(John)... BMC Pharmacol Toxicol 2015-08-04

...PIK3CA mutant tumors. PIK3CA mutations may represent a predictive biomarker for response to PI3K inhibitors. A large-sca...

Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A pha...

Hou(Ming-Mo),Liu(Xiaochun),Wheler(Jennifer... Oncotarget 2015-08-26

...PIK3CA mutations was associated with a significantly longer overall survival (median, 9.4 months) than the absence of PI...

Molecular characterization of serous ovarian carcinoma using a multigene next...

Ab Mutalib(Nurul-Syakima),Syafruddin(Saifu... BMC Res Notes 2015-07-06

...PIK3CA, STK11 and KIT) were exclusively altered in the tumor group. TP53 alterations were present in all the tumors but ...

Role of p38 MAPK in enhanced human cancer cells killing by the combination of...

Zhang(Chong),Shi(Jing),Mao(Shi-ying),Xu(Ya... J Cell Mol Med 2015-08-31

...PIK3CA colorectal cancer, but not among patients with wild-type PIK3CA cancer. In this study, we showed that clinically ...

Prognostic significance of PIK3CA and SOX2 in Asian patients with lung squamo...

Iijima(Yoshihito),Seike(Masahiro),Noro(Rin... Int J Oncol 2015-08-21

...PIK3CA-negative and SOX2-positive staining (PIK3CA(-)/SOX2(+)) showed better prognosis compared with those with PIK3CA-p...

Programmed cell death 1 (PD-1) and its ligand (PD-L1) in common cancers and t...

Gatalica(Zoran),Snyder(Carrie),Maney(Todd)... Cancer Epidemiol Biomarkers... 2015-08-11

...PIK3CA; P = 0.002). In non-small cell lung cancer, PD-1/PD-L1 coexpression was identified in 8 cases (19%), which lacked...

Recent therapeutic advances in the treatment of colorectal cancer.

Ciombor(Kristen K),Wu(Christina),Goldberg(... Annu Rev Med 2015-09-14

...PIK3CA, and others) has become increasingly important for identification of prognostic and predictive biomarkers, as wel...

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