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Recurrent PIK3CA-E545K mutation promotes cervical cancer growth and invasion ...

Huang(C),Zhang(W),Ma(X),Li(X),Sun(X) Mol Genet Genomics 2026-08-07

...PIK3CA as one of the most frequently mutated genes in cervical cancer. Functional analyses demonstrated that PIK3CA E545...

Genotype-directed Targeted Therapy for Pediatric Vascular Malformations: A Sy...

Kumar(B),Patil(N),Goel(P),Jain(V),Yadav(DK... J Indian Assoc Pediatr Surg None

...PIK3CA and RAS-pathway mutations. Sirolimus, alpelisib, and trametinib were the most commonly used targeted agents. Many...

Next-Generation Sequencing Refines Diagnosis and Expands Precision Medicine O...

Tesser-Gamba(F),Mendes(TB),Lima(FT),Abib(S... Int J Mol Sci 2026-08-12

...PIK3CA, were also detected. Importantly, molecular profiling had significant diagnostic impact in several histologically...

Molecular Characterization of Endometrial Cancer Using a Laboratory-Developed...

Maloberti(T),Altimari(A),Gruppioni(E),Popp... Int J Mol Sci 2026-08-18

...PIK3CA, ARID1A, and TP53. POLE-mutated tumors showed the highest mutational burden, while CTNNB1 alterations were predom...

Thymoquinone Potentiates Docetaxel-Induced Antitumor Activity with the Involv...

Orhaner(A),Tuncer(MC),Özdemir(İ) Pharmaceuticals (Basel) 2026-07-24

...PIK3CA, and AKT1 while upregulating BAX, CASP9, and PTEN. Bioinformatic analyses identified apoptosis, p53, PI3K/AKT, mT...

Integrated Analysis of the STING1-IRF1 Signaling Pathway and Genomic Alterati...

Alhamadani(I),Alzeyadi(M) Asian Pac J Cancer Prev 2026-08-01

...PIK3CA (53%), TP53 (46%) genes in addition to mutations in STING1which was directly linked to a disruption in tumor sign...

Implementing liquid biopsy in HR+/HER2- metastatic breast cancer: challenges ...

Frescura(V),Cristofanilli(M),Reduzzi(C),Po... Curr Opin Oncol 2026-09-03

...PIK3CA - achieved regulatory validation as a primary predictive biomarker for treatment selection, supporting the approv...

Lynch syndrome-associated urothelial carcinoma: clinical and molecular findin...

Rametta(A),Barella(M),Scardino(A),Barbetta... Fam Cancer 2026-09-02

...PIK3CA, which co-occurred with FGFR3 p.Arg248Cys. No gene fusions were identified. This study expands the limited molecu...

Inavolisib for PIK3CA-mutated advanced endometrial cancer: a multicentric, ph...

Passarelli(A),Bartoletti(M),Farolfi(A),Iac... Int J Gynecol Cancer 2026-08-09

...PIK3CA mutation will receive inavolisib. Patients aged 18 years and older with documented evidence of PIK3CA mutated adv...

Primary mucoepidermoid carcinoma of the liver: Clinicopathological features, ...

Zhu(Y),Shao(Y),Guo(J),Lin(W),Deng(J),Pan(Y... Cancer Treat Res Commun 2026-09-05

...PIK3CA, CDK4, MDM2 and MYC were found in another case. The clinicopathological features and mutational profiles of MEC-L...

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