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Taselisib, a selective inhibitor of PIK3CA, is highly effective on PIK3CA-mut...

Lopez(Salvatore),Schwab(Carlton L),Cocco(E... Gynecol Oncol 2015-01-29

...PIK3CA, against primary uterine serous carcinomas (USC) harboring PIK3CA mutations and HER2/neu gene amplification.,Sens...

Prognostic role of PIK3CA mutations and their association with hormone recept...

Pang(Bo),Cheng(Shi),Sun(Shi-Peng),An(Cheng... Sci Rep 2015-10-16

...PIK3CA mutations and ER/PR expression and the prognostic role of PIK3CA mutations in BCa patients, and in particular, HR...

Relationship between aspirin use after diagnosis of colorectal cancer and pat...

Ye(X-F),Wang(J),Shi(W-T),He(J) Br J Cancer 2015-01-26

...PIK3CA gene but not for those with wild-type PIK3CA.,Based on current evidence, the use of aspirin after diagnosis does ...

Identification of actionable mutations in malignant pleural mesothelioma.

Shukuya(Takehito),Serizawa(Masakuni),Watan... Lung Cancer 2015-06-10

...PIK3CA, NRAS, MEK1, AKT1, PTEN, and HER2 and amplifications in EGFR, MET, PIK3CA, FGFR1, and FGFR2. In addition, 21 pati...

Performance of amplicon-based next generation DNA sequencing for diagnostic g...

Sie(Daoud),Snijders(Peter J F),Meijer(Gerr... Cell Oncol (Dordr) 2015-06-22

...PIK3CA. Next, the performance of the validated test algorithm was assessed in an independent, prospective cohort of FFPE...

[CLOVES syndrome: a malformational syndrome closely resembling Proteus syndro...

Guillet(A),Aubert(H),Tessier(M-H),David(A)... Ann Dermatol Venereol 2015-05-26

...PIK3CA), with asymmetric body hypertrophy, lipomatous hamartoma of the trunk and numerous malformations.,We report a cas...

Transcriptional CCND1 expression as a predictor of poor response to neoadjuva...

Tanioka(M),Sakai(K),Sudo(T),Sakuma(T),Kaji... Breast Cancer Res Treat 2015-07-24

...PIK3CA mutations were detected using MassARRAY (Sequenom, San Diego, CA). The gene expression levels were dichotomized a...

PIK3CA mutations in breast cancer: reconciling findings from preclinical and ...

Zardavas(Dimitrios),Phillips(Wayne A),Loi(... Breast Cancer Res 2015-04-16

...PIK3CA mutations and their potential implications. Prospective clinical trials stratifying by PIK3CA genotype will be ne...

A comprehensive evaluation of biomarkers predictive of response to PI3K inhib...

Mazumdar(Tuhina),Byers(Lauren A),Ng(Patric... Mol Cancer Ther 2015-11-10

...PIK3CA mutations were sensitive to pathway inhibitors, whereas amplification status did not predict sensitivity. While w...

Lentiviral vector-based insertional mutagenesis identifies genes involved in ...

Ranzani(Marco),Annunziato(Stefano),Calabri... Mol Ther 2015-10-22

...PIK3CA and PIK3CB, by showing that their forced expression confers resistance to lapatinib in vitro and found that their...

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