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PIK3CA mutations in androgen receptor-positive triple negative breast cancer ...

Lehmann(Brian D),Bauer(Joshua A),Schafer(J... Breast Cancer Res 2015-06-22

...PIK3CA) mutations. The purpose of this study was to determine if targeting phosphoinositide 3-kinase (PI3K) alone or in ...

Recurrent inflammatory myofibroblastic tumors harboring PIK3CA and KIT mutati...

Li(Cheng-Fang),Liu(Chun-Xia),Li(Bing-Cheng... Int J Clin Exp Pathol 2015-05-14

...PIK3CA) gene, resulting in a G-A substitution at position 1624 (E542K). Moreover, no any mutation was found in the prima...

Hotspot mutations in common oncogenes are infrequent in nasopharyngeal carcin...

Jiang(Ning),Liu(Na),Yang(Fan),Zhou(Qiming)... Oncol Rep 2015-06-01

...PIK3CA H1047R mutant in 7 NPC cell lines. In addition, oncogene mutations showed no correlation with either risk habits ...

Anticipating mechanisms of resistance to PI3K inhibition in breast cancer: a ...

Leroy(Cedric),Amante(Romain J),Bentires-Al... Biochem Soc Trans 2015-05-11

...PIK3CA mutation, PTEN (phosphatase and tensin homologue deleted on chromosome 10) loss or the activation of upstream pro...

Changes in PIK3CA mutation status are not associated with recurrence, metasta...

Arthur(L M),Turnbull(A K),Renshaw(L),Keys(... Breast Cancer Res Treat 2015-09-21

...PIK3CA mutation status (four gains, two losses, total 76). The most common changes in PIK3CA mutation status were seen i...

RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcri...

Bao(Zhao-Shi),Chen(Hui-Min),Yang(Ming-Yu),... Genome Res 2015-07-20

...PIK3CA signaling and lowered expression of genes that suppressed RB1 or TP53 function. Expression of the ZM fusion was m...

KRAS genotypic changes of circulating tumor cells during treatment of patient...

Kalikaki(Aristea),Politaki(Helen),Souglako... PLoS One 2015-05-26

...PIK3CA and BRAF wild type primary tumors and 14 KRAS mutant tumors. CTCs were detected in 65% of specimens obtained from...

Epigenetic inactivation of inositol polyphosphate 4-phosphatase B (INPP4B), a...

Yuen(Jessie Wai-Fong),Chung(Grace Tin-Yun)... PLoS One 2015-12-07

...PIK3CA amplification, we examined the role of INPP4B, a negative regulator of the PI3K/AKT signaling pathway in the deve...

In vitro multifaceted activities of a specific group of novel phosphatidylino...

Kong(Dexin),Yamori(Takao),Yamazaki(Kanami)... Invest New Drugs 2015-07-13

...PIK3CA gene, which encodes the catalytic subunit of PI3Kα, has been found in various types of human cancers. The hotspot...

Sensitive genotyping of somatic mutations in the EGFR, KRAS, PIK3CA, BRAF gen...

Emelyanova(Marina),Arkhipova(Ksenia),Mazur... Appl Immunohistochem Mol Mo... 2015-12-18

...PIK3CA) are associated with sensitivity to these drugs. We developed a highly sensitive LUNG CANCER (LC)-biochip approac...

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