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A targeted next-generation sequencing assay detects a high frequency of thera...

Vasan(Neil),Yelensky(Roman),Wang(Kai),Moul... Oncologist 2015-01-12

...PIK3CA (n = 9, phosphatidylinositol 3-kinase [PI3K]/mammalian target of rapamycin [mTOR] inhibitors), NF1 (n = 7, PI3K/m...

Targetable signaling pathway mutations are associated with malignant phenotyp...

Wakimoto(Hiroaki),Tanaka(Shota),Curry(Will... Clin Cancer Res 2015-01-07

...PIK3CA, KRAS, AKT, or PTEN mutation or PDGFRA, MET, or N-MYC amplification. IDH/CIC mutant tumors were associated with P...

Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systema...

Ocana(Alberto),Vera-Badillo(Francisco),Al-... PLoS One 2015-06-01

...PIK3CA], lack of phosphatase and tensin homolog [PTEN] expression by immunohistochemistry or western-blot or increased e...

Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutat...

Ding(Xiao),Yang(Yuan),Han(Baoda),Du(Chengz... PLoS One 2015-06-12

...PIK3CA, JAK1, and SMO genes. The transcriptomes of the CTNNB1 mutation-positive HCC samples from the HBV-positive patien...

Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell ...

Agaram(Narasimhan P),Chen(Chun-Liang),Zhan... Genes Chromosomes Cancer 2015-02-26

...PIK3CA mutations, while no MDM2 amplifications were identified. All four pediatric MYOD1-mutated RMS patients died of th...

Biology of breast cancer during pregnancy using genomic profiling.

Azim(Hatem A),Brohée(Sylvain),Peccatori(Fe... Endocr Relat Cancer 2015-02-09

...PIK3CA mutation. Around 30% of tumors were basal, with no differences in the distribution of breast cancer molecular sub...

Detecting the spectrum of multigene mutations in non-small cell lung cancer b...

Su(Jian),Zhang(Xu-Chao),An(She-Juan),Zhong... Chin J Cancer 2015-06-15

...PIK3CA), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), v-ras neuroblastoma viral oncogene homolog (NRAS), dual ...

Small-cell lung cancers in patients who never smoked cigarettes.

Varghese(Anna M),Zakowski(Maureen F),Yu(He... J Thorac Oncol 2015-01-30

...PIK3CA, ALK testing, RB protein expression, and next generation sequencing were performed on available samples.,Two perc...

The frequencies and clinical implications of mutations in 33 kinase-related g...

Abdul-Jalil(Khairun I),Sheehan(Katherine M... Ann Surg Oncol 2015-03-30

...PIK3CA, PIK3R1, AKT, STK11, KRAS, BRAF, MEK, CTNNB1, EGFR, MET, and NRAS, using the Sequenom platform. DNA samples were ...

Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR...

Thoury(Anne),Descatoire(Véronique),Kotelev... Histol Histopathol 2015-07-14

...PIK3CA, K-Ras mutations and microsatellite instability (MSI). We distinguished two groups: group 1 (grade 1 and 2 endome...

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