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TP53 BRCA1 CRISPR single-cell cancer

Matsumoto(Toshihide),Yamazaki(Masaaki),Tak... Am J Clin Pathol 2015-11-13

...PIK3CA mutations were observed in 11 (31.4%) of 35 OEMCas and 10 (35.7%) of 28 OCCCas. Ten of 11 OEMCas had PIK3CA mutat...

Koren(Shany),Reavie(Linsey),Couto(Joana Pi... Nature 2015-10-01

...PIK3CA(H1047R) on mammary cell fate in the pre-neoplastic mammary gland and show that the cell of origin of PIK3CA(H1047...

Van Keymeulen(Alexandra),Lee(May Yin),Ouss... Nature 2015-10-01

...Pik3ca-derived tumours and the impact of mutations in this gene on tumour heterogeneity. Surprisingly, oncogenic Pik3ca(...

Kirouac(D C),Lahdenranta(J),Du(J),Yarar(D)... CPT Pharmacometrics Syst Ph... 2015-07-30

...PIK3CA and KRAS), and expression of the HER3 ligand heregulin determined sensitivity to combinations of inhibitors again...

Hagemann(Ian S),O'Neill(Patrick K),Erill(I... Cancer Genet 2015-11-17

...PIK3CA, KIT, BRAF, NRAS, IDH1, and JAK2. Sequencing results for each tumor were modeled as a dichotomized genotype (acti...

Kim(Suwon) Cancer Manag Res 2015-08-07

...PIK3CA. Second, the mechanisms of resistance to targeted therapy are reviewed. These include acquired resistance under t...

Mendez(Pedro),Ramirez(Jose Luis) Transl Lung Cancer Res 2015-03-25

...PIK3CA, SOX2, ACK1, PRKCI, TP63, PLD1, ECT2, and others genes are located. Although SOX2 has been postulated as a key re...

Ikeda(Sadakatsu),Hansel(Donna E),Kurzrock(... Cancer Treat Rev 2015-11-06

...PIK3CA, ERCC2, FGFR3, and HER2. Molecular targeted therapies against similar genetic alterations are currently available...

Wong(Chi Hang),Ma(Brigette Buig Yue),Cheon... Am J Cancer Res 2015-06-23

Nasopharyngeal carcinoma (NPC) is endemic to Southeast Asia and over 40% of NPC tissues harbor PIK3CA amplifications. Th...

Tabernero(Josep),Lenz(Heinz-Josef),Siena(S... Lancet Oncol 2015-10-27

...PIK3CA wild-type; HR 0·54, 95% CI 0·32-0·89 for PIK3CA mutant [PIK3CA wild-type vs mutant, pinteraction=0·85]) or circul...

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