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Measurement of PIP3 levels reveals an unexpected role for p110β in early adap...

Costa(Carlotta),Ebi(Hiromichi),Martini(Mir... Cancer Cell 2015-03-13

...PIK3CA mutations and/or HER2 amplification. This study reveals that, even among these sensitive cancers, the initial eff...

Predictive factors for response to neoadjuvant therapy in breast cancer.

Loibl(Sibylle),von Minckwitz(Gunter),Untch... Oncol Res Treat 2015-06-23

...PIK3CA, can now be measured almost on a routine basis due to the decreased analysis costs.

Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hyp...

Kinross(Kathryn M),Montgomery(Karen G),Man... FASEB J 2015-06-22

...Pik3ca(H1047R) mutation into the endogenous Pik3ca gene of the mouse. Ubiquitous expression of the Pik3ca(H1047R) mutati...

In vitro anticancer activity of PI3K alpha selective inhibitor BYL719 in head...

Keam(Bhumsuk),Kim(Soyeon),Ahn(Yong-Oon),Ki... Anticancer Res 2015-03-10

...PIK3CA mutant cell lines, SNU-1076 and Detroit562, and four PIK3CA wild-type cell lines, SNU-1066, SNU-1041, FaDu and SC...

P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 ...

Venkatesha(Venkatasubbaiah A),Joshi(Asavar... Mol Cancer 2015-07-13

...PIK3CA, BRAF, and others that drive tumor growth. Some patients though initially respond, but later develop resistance t...

Predictive value of K-ras and PIK3CA in non-small cell lung cancer patients t...

Chen(Jie-Ying),Cheng(Ya-Nan),Han(Lei),Wei(... Cancer Biol Med 2015-07-15

...PIK3CA mutation showed similar trends. In addition to EGFR, adding K-ras and PIK3CA as routine gene biomarkers in clinic...

Diagnostic yield of targeted next generation sequencing in various cancer typ...

Hagemann(Ian S),O'Neill(Patrick K),Erill(I... Cancer Genet 2015-11-17

...PIK3CA, KIT, BRAF, NRAS, IDH1, and JAK2. Sequencing results for each tumor were modeled as a dichotomized genotype (acti...

Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation.

Urata(Takahiro),Naito(Yoshiki),Nagamine(Mi... Clin J Gastroenterol 2015-07-21

...PIK3CA. Post-operative recurrence was discovered 34 months after tumor resection with negative margins and a 6-month cou...

Should endometrial clear cell carcinoma be classified as Type II endometrial ...

Bae(Hyo Sook),Kim(Hyesun),Young Kwon(Sun),... Int J Gynecol Pathol 2015-09-15

...PIK3CA, and PTEN genes for 16 pure CCCs. No patients with pure CCC experienced recurrent disease or died of the disease ...

PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity...

Scheffler(Matthias),Bos(Marc),Gardizi(Masy... Oncotarget 2015-11-27

...PIK3CA-mutated patients are described and compared with a control group of PIK3CA-wildtype patients.,Among the total coh...

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