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The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens ...

Munkley(Jennifer),Livermore(Karen E),McClu... Oncoscience 2015-10-27

...PIK3CA p110α catalytic subunit is also indirectly regulated by androgens at the protein level. We show that PIK3R1 mRNA ...

Global gene expression profiling of a mouse model of ovarian clear cell carci...

Chandler(Ronald L),Raab(Jesse R),Vernon(Mi... Genom Data 2015-10-20

...PIK3CA(H1047R) substitution mutation (Chandler et al., 2015) [2]. We utilized Affymetrix Mouse Gene 2.1 ST arrays for th...

Assessing the potential value of long interspersed element-1 hypomethylation ...

Tang(Jie-Ting),Wang(Zhen-Hua),Fang(Jing-Yuan) Onco Targets Ther 2015-11-25

...PIK3CA-mutation status.,LINE-1 hypomethylation is a potential biomarker for risk of CRC and associated with various clin...

Comparison of targeted next-generation sequencing and Sanger sequencing for t...

Arsenic(Ruza),Treue(Denise),Lehmann(Annika... BMC Clin Pathol 2015-11-20

...PIK3CA, is one of the most frequently mutated genes in breast cancer, and the mutation status of PIK3CA has clinical rel...

PIK3CA mutations in serum DNA are predictive of recurrence in primary breast ...

Oshiro(Chiya),Kagara(Naofumi),Naoi(Yasuto)... Breast Cancer Res Treat 2015-12-04

...PIK3CA mutant tumors. The serum samples from these patients with PIK3CA mutant tumors were subjected to the dPCR assay, ...

Targeted therapy for genetic cancer syndromes: Von Hippel-Lindau disease, Cow...

Agarwal(Rishi),Liebe(Sarah),Turski(Michell... Discov Med 2015-11-16

...PIK3CA/AKT/mTOR signaling pathway have shown activity in selected group of patients affected by these syndromes or in pa...

Multiple resistant factors in lung cancer with primary resistance to EGFR-TK ...

Kim(Go Woon),Song(Joon Seon),Choi(Chang-Mi... Lung Cancer 2015-12-28

...PIK3CA mutation alongside EGFR activating mutation. Most of patients exhibited multiple abnormalities of these factors. ...

Whole genomes redefine the mutational landscape of pancreatic cancer.

Waddell(Nicola),Pajic(Marina),Patch(Ann-Ma... Nature 2015-04-15

...PIK3CA), but at low individual patient prevalence. Genomic instability co-segregated with inactivation of DNA maintenanc...

PI3K/AKT pathway mutations cause a spectrum of brain malformations from megal...

Jansen(Laura A),Mirzaa(Ghayda M),Ishak(Gis... Brain 2015-08-07

...PIK3CA and AKT3 in this cohort, including cancer-associated hotspot PIK3CA mutations in dysplastic megalencephaly, hemim...

Molecular characterization of apocrine salivary duct carcinoma.

Chiosea(Simion I),Williams(Lindsay),Griffi... Am J Surg Pathol 2015-08-28

...PIK3CA, HRAS, and TP53 mutation and/or PTEN loss. Six of 10 cases with PIK3CA mutation also had an HRAS mutation. These ...

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