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Uncovering the genomic heterogeneity of multifocal breast cancer.

Desmedt(Christine),Fumagalli(Debora),Pietr... J Pathol 2015-10-08

...PIK3CA, TP53, GATA3, and PTEN. Genomically heterogeneous lesions tended to be further apart in the mammary gland than ho...

A functional variant at miR-520a binding site in PIK3CA alters susceptibility...

Ding(Lifang),Jiang(Zao),Chen(Qiaoyun),Qin(... Biomed Res Int 2015-12-15

...PIK3CA was detected in the peripheral blood mononucleated cell of CRC patients, suggesting that mRNA levels of PIK3CA mi...

PIK3CA rs7640662 (C/G) single nucleotide polymorphism lacks association with ...

Mir(Atefeh),Sadegh(Mahdiyeh Harati),Ahmadi... Interv Med Appl Sci 2015-04-03

...PIK3CA is a gene that encodes α catalytic subunit of this enzyme. A common polymorphism of PIK3CA, rs7640662 (C/G), was ...

Genomic analyses reveal mutational signatures and frequently altered genes in...

Zhang(Ling),Zhou(Yong),Cheng(Caixia),Cui(H... Am J Hum Genet 2015-05-29

...PIK3CA hotspot mutations (c.1624G>A [p.Glu542Lys] and c.1633G>A [p.Glu545Lys]) were enriched in APOBEC-signature tumors,...

Progression of naive intraepithelial neoplasia genome to aggressive squamous ...

Jung(Seung-Hyun),Choi(Youn Jin),Kim(Min Su... Oncotarget 2015-12-14

...PIK3CA was altered in all MIC/CSCCs by either mutation or amplification, but not in CINs. The CINs harbored significantl...

Correlation of extended RAS and PIK3CA gene mutation status with outcomes fro...

Price(T J),Bruhn(M A),Lee(C K),Hardingham(... Br J Cancer 2015-05-13

...PIK3CA gene mutation status in patients receiving capecitabine plus or minus bevacizumab (±mitomycin C) in the randomise...

PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable wit...

Payne(S N),Maher(M E),Tran(N H),Van De Hey... Oncogenesis 2015-10-06

...PIK3CA-mediated pancreatic tumorigenesis and the response of PIK3CA mutant pancreatic cancers to dual PI3K/mammalian tar...

Impact of somatic mutations on patterns of metastasis in colorectal cancer.

Lipsyc(Marla),Yaeger(Rona) J Gastrointest Oncol 2015-12-23

...PIK3CA, and NRAS oncogenes and clinical outcomes and metastatic patterns of mCRC. The presence of a KRAS mutation is ass...

Asymmetric real-time PCR and multiplex melting curve analysis with TaqMan pro...

Botezatu(Irina V),Nechaeva(Irina O),Stroga... Data Brief 2015-12-24

...PIK3CA gene ("hot spots" in exons 9 and 20) are found in many human cancers, and their presence can determine prognosis ...

SOX2 expression is associated with FGFR fusion genes and predicts favorable o...

Zheng(Shanbo),Pan(Yunjian),Wang(Rui),Li(Yu... Onco Targets Ther 2015-11-03

...PIK3CA, NFE2L2, and FGFR fusion genes. Clinical characteristics, including age, sex, smoking status, stage, relapse-free...

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