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Measurement of PIP3 levels reveals an unexpected role for p110β in early adap...

Costa(Carlotta),Ebi(Hiromichi),Martini(Mir... Cancer Cell 2015-03-13

...PIK3CA mutations and/or HER2 amplification. This study reveals that, even among these sensitive cancers, the initial eff...

Insulin-like growth factor--phosphatidylinositol 3 kinase signaling in canine...

Kool(M M J),Galac(S),van der Helm(N),Corra... J Vet Intern Med 2015-10-05

...PIK3CA).,Target gene expression indicated PI3K activation in carcinomas, but not in adenomas. No amino acid-changing mut...

ARID2, p110α, p53, and β-catenin protein expression in hepatocellular carcin...

You(Jason),Yang(Hushan),Lai(Yinzhi),Simon(... Hum Pathol 2015-08-18

...PIK3CA (p110α) mutations are implicated in hepatocellular carcinoma (HCC); and previous work has contributed to thorough...

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon...

Jorissen(Robert N),Christie(Michael),Moura... Br J Cancer 2015-12-03

...PIK3CA, TP53, CpG island methylator phenotype or chromosomal instability status (P⩽0.036). Microarray analysis similarly...

Genetic mutational profiling analysis of T cell acute lymphoblastic leukemia ...

Yuan(Lan),Lu(Ling),Yang(Yongchen),Sun(Heng... Ann Hematol 2015-12-18

...PIK3CA, PIK3RA, and AKT1. NOTCH1 mutations were identified in 51.9 and 37.9 % of pediatric and adult patients, respectiv...

In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and...

Janiszewska(Michalina),Liu(Lin),Almendro(V... Nat Genet 2015-12-30

...PIK3CA mutation and HER2 (ERBB2) amplification within HER2-positive breast cancer during neoadjuvant therapy. We found t...

Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promote...

Shain(A Hunter),Garrido(Maria),Botton(Thom... Nat Genet 2015-12-30

...PIK3CA, some of which are candidates for targeted therapies.

Precision medicine in colorectal cancer: the molecular profile alters treatme...

Tran(Nguyen H),Cavalcante(Ludmila L),Lubne... Ther Adv Med Oncol 2015-09-02

...PIK3CA, leading to the evolution of the treatment of mCRC to a more precision-based approach. As our understanding of re...

KRAS, NRAS, BRAF mutation comparison of endoscopic and surgically removed pri...

Saridaki(Z),Saegart(X),De Vriendt(V),Hatzi... Br J Cancer 2015-12-03

...PIK3CA molecular evaluation was performed with RT-PCR and Sequenom.,From 165 deemed adequate by the pathologist pairs, 8...

[PI3K and mTOR pathway and molecular targeted agents].

Nishio(Kazuto),Sakai(Kazuko),Togashi(Yosuk... Nihon Rinsho 2015-09-18

...PIK3CA mutations are the predictive markers for anti-EGFR antibodies, trastuzumab, and lapatinib. The p110 isoform selec...

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