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Metastatic Extramammary Paget's Disease of Scrotum Responds Completely to Sin...

Barth(Peter),Dulaimi Al-Saleem(Essel),Edwa... Case Rep Oncol Med 2015-02-18

...PIK3CA mutation. These findings may lead to possible therapeutic interventions targeting these pathways in a disease wit...

Multifocal endometriotic lesions associated with cancer are clonal and carry ...

Anglesio(Michael S),Bashashati(Ali),Wang(Y... J Pathol 2015-07-20

...PIK3CA mutations appeared consistently in concurrent endometriosis when present in the primary CCC. In several cases, on...

HER2 expression and markers of phosphoinositide-3-kinase pathway activation d...

Reis(H),Herold(T),Ting(S),Worm(K),Huber(U)... Lung Cancer 2015-12-01

...PIK3CA mutations, and ALK fluorescence ISH (FISH).,HER2-IHC was feasible in 176 (91.2%) cases. Of 53 (30%) cases with IH...

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human in...

Matano(Mami),Date(Shoichi),Shimokawa(Marik... Nat Med 2015-05-01

...PIK3CA. Organoids engineered to express all five mutations grew independently of niche factors in vitro, and they formed...

PIKing the type and pattern of PI3K pathway mutations in endometrioid endomet...

Marchiò(Caterina),De Filippo(Maria R),Ng(C... Gynecol Oncol 2015-08-24

...PIK3CA hotspot mutations E542K, E545K, and H1047R were found to be significantly more prevalent in PIK3CA-mutant MSS (21...

PIK3CA mutations in serum DNA are predictive of recurrence in primary breast ...

Oshiro(Chiya),Kagara(Naofumi),Naoi(Yasuto)... Breast Cancer Res Treat 2015-12-04

...PIK3CA mutant tumors. The serum samples from these patients with PIK3CA mutant tumors were subjected to the dPCR assay, ...

Progression of naive intraepithelial neoplasia genome to aggressive squamous ...

Jung(Seung-Hyun),Choi(Youn Jin),Kim(Min Su... Oncotarget 2015-12-14

...PIK3CA was altered in all MIC/CSCCs by either mutation or amplification, but not in CINs. The CINs harbored significantl...

Mutation profile and clinical outcome of mixed endometrioid-serous endometria...

Coenegrachts(L),Garcia-Dios(D A),Depreeuw(... Virchows Arch 2015-06-09

...PIK3CA, PTEN, and TP53 and microsatellite instability (MSI) status were determined in mixed EEC-SC, as well as in their ...

Novel mutations in neuroendocrine carcinoma of the breast: possible therapeut...

Ang(Daphne),Ballard(Morgan),Beadling(Carol... Appl Immunohistochem Mol Mo... 2015-11-17

...PIK3CA exon 9 E542K mutations, 2 of which also harbored point mutations in FGFR family members (FGFR1 P126S, FGFR4 V550M...

Targeted therapy for genetic cancer syndromes: Von Hippel-Lindau disease, Cow...

Agarwal(Rishi),Liebe(Sarah),Turski(Michell... Discov Med 2015-11-16

...PIK3CA/AKT/mTOR signaling pathway have shown activity in selected group of patients affected by these syndromes or in pa...

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