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TP53 BRCA1 CRISPR single-cell cancer

Elkabets(Moshe),Pazarentzos(Evangelos),Jur... Cancer Cell 2015-06-23

...PIK3CA mutations or amplification. Studying models of therapeutic resistance, we have observed that SCC cells that becom...

Wirtz(Eric D),Hoshino(Daisuke),Maldonado(A... JAMA Otolaryngol Head Neck ... 2015-08-26

...PIK3CA mutation.,(1) To determine the role of oncogene dependence on PIK3CA-one of the more common and targetable oncoge...

Desmedt(Christine),Fumagalli(Debora),Pietr... J Pathol 2015-10-08

...PIK3CA, TP53, GATA3, and PTEN. Genomically heterogeneous lesions tended to be further apart in the mammary gland than ho...

Ding(Lifang),Jiang(Zao),Chen(Qiaoyun),Qin(... Biomed Res Int 2015-12-15

...PIK3CA was detected in the peripheral blood mononucleated cell of CRC patients, suggesting that mRNA levels of PIK3CA mi...

Mir(Atefeh),Sadegh(Mahdiyeh Harati),Ahmadi... Interv Med Appl Sci 2015-04-03

...PIK3CA is a gene that encodes α catalytic subunit of this enzyme. A common polymorphism of PIK3CA, rs7640662 (C/G), was ...

Zhang(Ling),Zhou(Yong),Cheng(Caixia),Cui(H... Am J Hum Genet 2015-05-29

...PIK3CA hotspot mutations (c.1624G>A [p.Glu542Lys] and c.1633G>A [p.Glu545Lys]) were enriched in APOBEC-signature tumors,...

Kwon(Mi Jung),Rho(Young-Soo),Jeong(Jin Che... Hum Pathol 2015-10-06

...PIK3CA mutations. Using sequencing analyses and immunohistochemistry, we examined KRAS, BRAF, PIK3CA, and CTNNB1 mutatio...

Mohamed(Abdalla D),Tremblay(Annie M),Murra... Biochim Biophys Acta 2015-10-20

...PIK3CA, CTNNB1 or FBXW7. Current Hippo pathway-targeting drugs include compounds that target the interaction between YAP...

Mukohara(Toru) Breast Cancer (Dove Med Press) 2015-06-01

...PIK3CA mutations are most frequently (∼30%) observed, along with protein loss of PTEN. Since the first discovery of PIK3...

Rothschild(Sacha I) Cancers (Basel) 2015-05-28

...PIK3CA, FGFR1 and DDR2. Thereby the review will focus on therapeutic strategies targeting these aberrations. Moreover, t...

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