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WNT signaling and distant metastasis in colon cancer through transcriptional ...

Ormanns(Steffen),Neumann(Jens),Horst(David... Oncotarget 2015-01-23

...PIK3CA mutations or loss of PTEN expression) and nuclear β-Catenin expression, both variables were determined in 55 matc...

Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in h...

Janku(Filip),Kaseb(Ahmed O),Tsimberidou(Ap... Oncotarget 2015-01-23

...PIK3CA, NF1]), Wnt pathway (n=6 [CTNNA1, CTNNB1]), MAPK pathway (n=2 [MAP2K1, NRAS]), and aberrant DNA repair mechanisms...

Multigene mutational profiling of cholangiocarcinomas identifies actionable m...

Simbolo(Michele),Fassan(Matteo),Ruzzenente... Oncotarget 2015-02-19

...PIK3CA (7%). IDH1/2 (p=0.0005) and BAP1 (p=0.0097) mutations were characteristic of ICC, while KRAS (p=0.0019) and TP53 ...

Identification of druggable cancer driver genes amplified across TCGA dataset...

Chen(Ying),McGee(Jeremy),Chen(Xianming),Do... PLoS One 2015-01-19

...PIK3CA. Wild-type KRAS was amplified in several cancer types, and KRAS-amplified cancer cell lines were most sensitive t...

Novel insights on the malignant transformation of endometriosis into ovarian ...

Gadducci(Angiolo),Lanfredini(Nora),Tana(Ro... Gynecol Endocrinol 2015-05-14

...PIK3CA in 20-40% and of ARID1 in 15-75% of the cases. Whereas estrogen receptors and progesterone receptors are quite al...

Somatic mosaicism for the p.His1047Arg mutation in PIK3CA in a girl with mese...

Cohen(Ana S A),Townsend(Katelin N),Xiang(Q... Am J Med Genet A 2015-04-20

...PIK3CA, which was absent in blood. This report expands the phenotypic spectrum of mosaic PIK3CA mutations.

A single nucleotide polymorphism in PIK3CA gene is inversely associated with ...

Pang(Bo),Sun(Shi-Peng),Gao(Lei),Zhu(Rui-Li... Med Oncol 2015-07-24

Single nucleotide polymorphism (SNP) rs17849071 was recently reported to be inversely associated with PIK3CA amplificati...

Combined mutational analysis of RAS, BRAF, PIK3CA, and TP53 genes in Taiwanes...

Chang(Ya-Sian),Hsu(Hui-Ting),Ko(Ying-Chin)... Oral Surg Oral Med Oral Pat... 2015-02-02

...PIK3CA, and TP53 mutations in OSCC within the Taiwanese population.,A total of 79 OSCC tissue specimens were screened fo...

Frequent activating HRAS mutations in trichilemmoma.

Tsai(J-H),Huang(W-C),Jhuang(J-Y),Jeng(Y-M)... Br J Dermatol 2015-07-07

...PIK3CA genes were also analysed for NS-unrelated cases.,Among the 27 cases, mutually exclusive HRAS c.37G>C and c.182A>G...

The evolution of our molecular understanding of colorectal cancer: what we ar...

Dienstmann(Rodrigo),Salazar(Ramon),Taberne... Am Soc Clin Oncol Educ Book 2015-11-03

...PIK3CA gene variants, likely improves outcomes. In this article, we review the current trends of translational research ...

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