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Decision coaching for healthy women with BRCA1/2 pathogenic variants and open...

Stracke(C),Kautz-Freimuth(S),Shukri(A),Iss... PLoS One None

Women with BRCA1/2 pathogenic variants (PVs) without a personal cancer history and with open family planning are in a ve...

Design and synthesis of the first PARP1 and PRMT5 dual inhibitors for the tre...

Xu(Y),Lei(Q),Yang(S),Zhang(Y),Luo(X),Song(... Eur J Med Chem 2026-08-16

...BRCA1, BRCA2 and RAD51, thereby triggering enhanced DNA damage and cell apoptosis. Notably, in the BRCA wild-type MDA-MB...

Identification of a three-gene prognostic signature associated with tumor imm...

Zhu(H),Fang(Y),Yang(M),Gao(T),Zhou(Y),Zhao... Transl Oncol 2026-08-17

...BRCA1 was selected for functional validation. Consistent with the bioinformatic analyses, BRCA1 was markedly upregulated...

Global Real-World Outcomes of Olaparib in Metastatic Castration-Resistant Pro...

Incorvaia(L),Santini(D),Matrana(MR),Maruzz... Int J Cancer 2026-08-18

...BRCA1/2 vs. non-BRCA HRR: 16.3 months [95% CI, 13.0-69.6] vs. 14.2 [95% CI, 12.0-22.9; p = 0.681]). Primary refractorine...

Biomarker testing in advanced or metastatic hormone receptor-positive, human ...

Reinert(T),Alshehri(AS),Shafik(A),Lin(CH),... Ther Adv Med Oncol None

...BRCA1/2 or PALB2 testing, while ctDNA is preferred for ESR1 detection. Next-generation sequencing (NGS) is the preferred...

An Unusual Presentation of Dermatofibrosarcoma Protuberans (DFSP): The Role o...

Ruci(A),Smart(C) Cureus 2026-07-00

...BRCA1)/ataxia-telangiectasia mutated (ATM) mutations and invasive lobular carcinoma of the left breast status post bilat...

Adaptive Surgical Decision-Making for Synchronous Metastatic Pancreatic Cance...

Akahori(T),Yokotani(T),Yoshizawa(A),Uchiya... Surg Case Rep None

...BRCA1 pathogenic variant. Maintenance olaparib was subsequently introduced, resulting in durable disease stabilization a...

AI-driven CRISPR strategies in breast cancer: Organoid modeling, adaptive edi...

Taki(AG),Shareef(A),Arora(V),Oweis(R),Jyot... Iran J Basic Med Sci None

...BRCA1-deficient tumors. Adaptive AI pipelines that iteratively refine guide RNAs and exosome-mimetic carriers, incorpora...

Hormonal contraceptives and cancer risk in women with a BRCA1 or BRCA2 pathog...

Nahshon(C),Fahoum(L),Hadar(D),Cohen(H),Mic... Breast Cancer 2026-08-18

Women with BRCA1/2 pathogenic variants face increased risks of breast and ovarian cancers. Our study aimed to evaluate t...

Exploring the causal role and mechanism of galanin in glioblastoma: integrati...

Song(H),Jia(Y),Qiu(X),Long(T),Yang(W) Front Pharmacol None

...BRCA1, SERPINA1, and LGALS3. Molecular docking confirmed stable binding of Galanin to the proteins encoded by these gene...

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