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High-throughput mutation profiling identifies novel molecular dysregulation i...

Fassan(Matteo),Simbolo(Michele),Bria(Emili... Gastric Cancer 2015-02-20

...PIK3CA, RB1, STK11, and TP53 genes were shared by both HG-IEN and ECG lesions. CDKN2A, IDH2, MET, and RET mutations were...

Human papillomavirus-associated adenocarcinoma of the base of tongue: potenti...

Chang(Ann Margaret V),Nikiforova(Marina N)... Head Neck Pathol 2015-01-02

...PIK3CA exon 9 (p.E545K) and MET exon 2 (p.E168D) mutations were identified. No PIK3CA or MET amplification was identifie...

New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed b...

Ross(Jeffrey S),Wang(Kai),Gay(Laurie),Al-R... Oncologist 2015-01-12

...PIK3CA (4%), PTCH1 (4%), and TSC1 (4%). Four (14%) of the ICC cases featured novel gene fusions involving the tyrosine k...

Dual inhibition of phosphatidylinositol 3'-kinase and mammalian target of rap...

Kudoh(Akiko),Oishi(Tetsuro),Itamochi(Hiroa... Int J Gynecol Cancer 2015-02-12

...PIK3CA gene. NVP-BEZ235 down-regulated the protein expression of phosphorylated (p-) Akt, p-p70S6K, and p-4E-BP1, suppre...

Epithelial ovarian cancer: rationale for changing the one-fits-all standard t...

Despierre(Evelyn),Yesilyurt(Betül T),Lambr... Int J Gynecol Cancer 2015-02-12

...PIK3CA (>79%), PTEN, FBXW7 (>57%), AKT2, AKT3, and FOXL2, using Sequenom MassARRAY.,Of the 13% histopathologically class...

Analysis of major known driver mutations and prognosis in resected adenosquam...

Wang(Rui),Pan(Yunjian),Li(Chenguang),Zhang... J Thorac Oncol 2015-01-30

...PIK3CA, AKT1, RET, and ALK. Tumors showing acinar, lepidic, micropapillary, or papillary growth in glandular component w...

Genetically engineered ERα-positive breast cancer mouse models.

Dabydeen(Sarah A),Furth(Priscilla A) Endocr Relat Cancer 2015-01-22

...PIK3CA gain of function, as well as loss of P53 (Trp53) or STAT1 are associated with ER+ mammary cancer. Treatment with ...

PIK3CA mutations frequently coexist with EGFR/KRAS mutations in non-small cel...

Wang(Lei),Hu(Haichuan),Pan(Yunjian),Wang(R... PLoS One 2015-01-06

...PIK3CA mutant cases and 108 patients without PIK3CA mutation.,PIK3CA mutation was found in 3.9% of squamous cell carcino...

Low incidence of oncogenic EGFR, HRAS, and KRAS mutations in seborrheic kerat...

Georgieva(Ivelina A),Mauerer(Andreas),Groe... Am J Dermatopathol 2015-04-06

...PIK3CA genes. The aim of this study was to identify further oncogenic mutations in human SK. Therefore, we screened for ...

miRNA expression profiling of 51 human breast cancer cell lines reveals subty...

Riaz(Muhammad),van Jaarsveld(Marijn T M),H... Breast Cancer Res 2015-03-30

...PIK3CA/PTEN and TP53 mutation status. Twelve miRNAs were associated with DNA copy number variation of the respective loc...

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