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PI3K pathway activation in high-grade ductal carcinoma in situ--implications ...

Sakr(Rita A),Weigelt(Britta),Chandarlapaty... Clin Cancer Res 2015-08-20

...PIK3CA-mutant allelic frequencies in DCIS and synchronous IBC revealed cases in which PIK3CA mutations were either restr...

Effect of aromatase inhibition on functional gene modules in estrogen recepto...

Gao(Qiong),Patani(Neill),Dunbier(Anita K),... Clin Cancer Res 2015-08-20

...PIK3CA modules. Modules measuring estrogen signaling strongly predicted antiproliferative response to therapy with and w...

Reverse-phase protein array profiling of oropharyngeal cancer and significanc...

Sewell(Andrew),Brown(Brandee),Biktasova(As... Clin Cancer Res 2015-08-20

...PIK3CA and AKT. Activation of PIK3CA downstream targets and sensitivity to pathway inhibitors were determined in HPV(+) ...

Comparative genomic analysis of primary and synchronous metastatic colorectal...

Lee(Sun Young),Haq(Farhan),Kim(Deokhoon),J... PLoS One 2015-01-13

...PIK3CA (6.7%) genes between primary colorectal and metastatic liver tumors. TP53 mutation was observed in 47% of the pri...

Increased drug resistance is associated with reduced glucose levels and an en...

Bhattacharya(B),Low(S H H),Soh(C),Kamal Mu... Br J Pharmacol 2015-01-20

...PIK3CA mutant cells displayed increased resistance in LG conditions. The PIK3CA mutant LG cells had selectively increase...

Designing a high-throughput somatic mutation profiling panel specifically for...

Spaans(Vivian M),Trietsch(Marjolijn D),Cro... PLoS One 2015-06-01

...PIK3CA, PPP2R1A and PTEN. A total of 546 tumours (205 cervical, 227 endometrial, 89 ovarian, and 25 vulvar carcinomas) w...

Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral ...

Rodon(Jordi),Braña(Irene),Siu(Lillian L),D... Invest New Drugs 2015-03-02

...PIK3CA and/or PTEN alterations.,The most common cancers were colorectal (n = 31) and breast cancer (n = 21). Median numb...

Next generation MUT-MAP, a high-sensitivity high-throughput microfluidics chi...

Schleifman(Erica B),Tam(Rachel),Patel(Raje... PLoS One 2015-01-16

...PIK3CA) using allele-specific PCR (AS-PCR) and Taqman technology. This mutation panel requires as little as 2 ng of high...

The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treat...

Therkildsen(Christina),Bergmann(Troels K),... Acta Oncol 2015-10-19

...PIK3CA and PTEN in relation to the clinical benefit from anti-EGFR treatment.,In total, 22 studies that include 2395 pat...

Segmental overgrowth syndrome due to an activating PIK3CA mutation identified...

Rasmussen(Maria),Sunde(Lone),Weigert(Karen... Am J Med Genet A 2015-08-19

Mosaic PIK3CA-mutations have been described in an increasing number of overgrowth syndromes. We describe a patient with ...

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