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MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Assoc...

Arcila(Maria E),Drilon(Alexander),Sylveste... Clin Cancer Res 2016-01-26

...PIK3CA, and AKT. Additional cases were identified through a search of publically available cancer genomic datasets. Muta...

PI3 Kinase in Cancer: From Biology to Clinic.

Workman(Paul),Clarke(Paul) Am Soc Clin Oncol Educ Book 2016-04-15

...PIK3CA, which encodes p110α and is the most frequently mutated kinase in the human genome. From these beginnings, there ...

Mutation frequency in 15 common cancer genes in high-risk head and neck squam...

McBride(Sean M),Rothenberg(S Michael),Faqu... Head Neck 2015-04-14

...PIK3CA, 9% in TP53, 2% in AKT1, and 2% in epidermal growth factor receptor (EGFR). The frequency of PIK3CA/AKT1 mutation...

Comprehensive mutation analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 ...

Swamikannu(Bhuminathan),Kumar(Kishore S),J... Asian Pac J Cancer Prev 2015-01-10

...PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1.,The present data indicate that the mutational alterations of genes, PIK3CA, p...

AKT, EGFR, C-ErbB-2, and C-kit expression in uterine carcinosarcoma.

Saglam(Ozlen),Husain(Seema),Toruner(Gokce) Int J Gynecol Pathol 2015-04-20

...PIK3CA gene were sequences in a cohort of 37 UCS, including 23 early-stage (I and II) and 14 late-stage (III and IV) tum...

miRNA expression profiling of 51 human breast cancer cell lines reveals subty...

Riaz(Muhammad),van Jaarsveld(Marijn T M),H... Breast Cancer Res 2015-03-30

...PIK3CA/PTEN and TP53 mutation status. Twelve miRNAs were associated with DNA copy number variation of the respective loc...

Low incidence of oncogenic EGFR, HRAS, and KRAS mutations in seborrheic kerat...

Georgieva(Ivelina A),Mauerer(Andreas),Groe... Am J Dermatopathol 2015-04-06

...PIK3CA genes. The aim of this study was to identify further oncogenic mutations in human SK. Therefore, we screened for ...

PI3K pathway in gynecologic malignancies.

Salvesen(Helga B),Werner(Henrica Maria),Kr... Am Soc Clin Oncol Educ Book 2015-11-03

...PIK3CA mutations and amplifications are common in endometrial, ovarian, and cervical cancers. PTEN mutations and deletio...

Targeting the PI3K/AKT/mTOR pathway: biomarkers of success and tribulation.

Owonikoko(Taofeek K),Khuri(Fadlo R) Am Soc Clin Oncol Educ Book 2015-11-03

...PIK3CA mutation, PTEN loss of function, TSC1 and TSC2 mutation, PIK3CA-GS genetic profile) biomarkers to identify patien...

Designing a high-throughput somatic mutation profiling panel specifically for...

Spaans(Vivian M),Trietsch(Marjolijn D),Cro... PLoS One 2015-06-01

...PIK3CA, PPP2R1A and PTEN. A total of 546 tumours (205 cervical, 227 endometrial, 89 ovarian, and 25 vulvar carcinomas) w...

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