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In-depth molecular profiling of the biphasic components of uterine carcinosar...

McConechy(Melissa K),Hoang(Lien N),Chui(Mi... J Pathol Clin Res 2016-08-08

...PIK3CA, PTEN, PIK3R1, and/or PIK3R2 in two-thirds of the cases. Mutations in FBXW7, PPP2R1A, ARID1A and KRAS were demons...

Somatic mutation in PIK3CA is a late event in cervical carcinogenesis.

Verlaat(Wina),Snijders(Peter Jf),van Moors... J Pathol Clin Res 2016-08-08

...PIK3CA exon 9 was the most frequently mutated locus in cervical carcinoma and the only mutated locus detected in CIN2/3....

The molecular landscape of extraskeletal osteosarcoma: A clinicopathological ...

Jour(George),Wang(Lu),Middha(Sumit),Zehir(... J Pathol Clin Res 2016-08-08

...PIK3CA and TERT promoter variant mutations were identified in 11% of the cases. Cases harbouring simultaneous TP53 and R...

Somatic mutation profiles in primary colorectal cancers and matching ovarian ...

Crobach(Stijn),Ruano(Dina),van Eijk(Ronald... J Pathol Clin Res 2016-08-08

...PIK3CA) that select for established (EGFR directed) or future targeted therapies. In a total of 31 variants 12 were not ...

Meningioma Genomics: Diagnostic, Prognostic, and Therapeutic Applications.

Bi(Wenya Linda),Zhang(Michael),Wu(Winona W... Front Surg 2016-07-26

...PIK3CA, which are collectively present in ~80% of sporadic meningiomas. Genomic features of meningioma further associate...

Combined treatment with everolimus and fulvestrant reversed anti-HER2 resista...

Sun(Bing),Ding(Lijuan),Wu(Shikai),Meng(Xia... Onco Targets Ther 2016-07-22

...PIK3CA gene mutation but was positive for phosphatase and tensin homologue expression, which might result in resistance ...

[THE SOMATIC MUTATIONS AND ABERRANT METHYLATION AS POTENTIAL GENETIC MARKERS ...

Mikhailenko(D S),Kushlinskii(N E) Klin Lab Diagn 2016-08-18

...PIK3CA) and mutation in -124 and -146 nucleotides in promoter of gene of catalytic subunit telomerase (TERT). The develo...

Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR...

Aleksic(Tamara),Browning(Lisa),Woodward(Ma... Front Oncol 2016-05-20

...PIK3CA mutation was detected in plasma, but not tumor DNA. The 2015 (post-trial) tumor harbored a mutation of uncertain ...

A genetic database can be utilized to identify potential biomarkers for biphe...

Mok(Shaffer R S),Mohan(Sachin),Grewal(Navj... J Gastrointest Oncol 2016-08-26

...PIK3CA), GPC3, choline kinase alpha (CHKA), prostaglandin-endoperoxide synthase 2 (PTGS2), telomerase reverse transcript...

Mutational analysis of primary and metastatic colorectal cancer samples under...

Nemecek(Radim),Berkovcova(Jitka),Radova(Le... Onco Targets Ther 2016-08-24

...PIK3CA, PTEN, and FBXW7 genes. Metastatic samples harbor significantly more mutations than primary tumors. Potentially n...

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