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PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis.

Green(Shon),Trejo(Christy L),McMahon(Marti... Cancer Res 2016-04-26

...PIK3CA(H1047R) mutation. PIK3CA(H1047R) expression alone failed to promote tumor formation, but dramatically enhanced tu...

Circulating tumor DNA identified by targeted sequencing in advanced-stage non...

Xu(Song),Lou(Feng),Wu(Yi),Sun(Da-Qiang),Zh... Cancer Lett 2016-05-03

...PIK3CA, and TP53, with an overall concordance of 76%. In conclusion, targeted sequencing of plasma ctDNA may be a feasib...

Mutational profiling of colorectal cancers with microsatellite instability.

Lin(Elaine I),Tseng(Li-Hui),Gocke(Christop... Oncotarget 2016-09-27

...PIK3CA, and PTEN genes as well as mutations in the receptor tyrosine kinase families. While the increased mutations in B...

Clinicopathological and Survival Analysis of Japanese Patients with Resected ...

Inoue(Yusuke),Matsuura(Shun),Kurabe(Nobuya... J Thorac Oncol 2016-09-20

...PIK3CA amplification in Japanese patients with non-small-cell lung cancer (NSCLC).,The copy numbers of the seven above-m...

High selectivity of PI3Kβ inhibitors in SETD2-mutated renal clear cell carcin...

Wang(Jun),Wen(Jianbo),Yi(Rui),Liu(Fang),Zh... J BUON 2016-01-07

...PIK3CA and CDK6 mutations.,Further investigation on AZD6482 profile revealed that mutations in RB1, KRAS, NRAS and APC c...

Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breas...

Cossu-Rocca(Paolo),Orrù(Sandra),Muroni(Mar... PLoS One 2016-06-13

...PIK3CA gene activating mutations, with an overall frequency of 20-40%. The aims of our study were to investigate PIK3CA ...

Multifocal intraductal tubulopapillary neoplasm of the pancreas with total pa...

Kölby(David),Thilén(Johan),Andersson(Rolan... Int J Clin Exp Pathol 2016-08-12

...PIK3CA mutations were infrequently seen. Invasive growth was present in 54% of the cases. Tumor size and Ki-67 index sho...

Mutation Spectra of Common Cancer-Associated Genes in Different Phenotypes of...

Chang(Shih-Ching),Lin(Pei-Ching),Lin(Jen-K... Ann Surg Oncol 2016-11-10

...PIK3CA (179, 14.3%); 137 (11.0%) cancers had high microsatellite instability (MSI). Women had significantly higher high ...

Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor...

Yu(Yi),Savage(Ronald E),Eathiraj(Sudharsha... PLoS One 2016-06-27

...PIK3CA/PIK3R1 mutations compared to those with wt-PIK3CA/PIK3R1 or PTEN mutations. For both ARQ 092 and ARQ 751, PIK3CA/...

Correlative Analysis of Genetic Alterations and Everolimus Benefit in Hormone...

Hortobagyi(Gabriel N),Chen(David),Piccart(... J Clin Oncol 2016-06-09

...PIK3CA, FGFR1, and CCND1 or the pathways of which they are components. However, quantitative differences in everolimus b...

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