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PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling.

Qu(Liujing),Li(Ge),Xia(Dan),Hongdu(Beiqi),... Biochem Biophys Res Commun 2016-06-14

...PIK3CA/AKT-MTOR) signaling. These data underscore the importance of PRKCI in the regulation of autophagy. Moreover, the ...

[Mechanism of TRIM24 to Regulate Resistance of Gefitinib in NSCLC cells].

Li(Haiying),Wang(Qingling),Bao(Haijun),Zha... Zhongguo Fei Ai Za Zhi 2016-10-05

...PIK3CA related AKT signal path in A549 cell.,TRIM24 could regulate required resistance to Gefitinib via Akt pathway in N...

Microglandular adenosis associated with triple-negative breast cancer is a ne...

Guerini-Rocco(Elena),Piscuoglio(Salvatore)... J Pathol 2016-08-01

...PIK3CA, and INPP4B) and tyrosine kinase receptor signalling-related genes (eg ERBB3 and FGFR2) were identified. At diagn...

Systematic identification of genes with a cancer-testis expression pattern in...

Wang(Cheng),Gu(Yayun),Zhang(Kai),Xie(Kaipe... Nat Commun 2016-06-09

...PIK3CA in breast cancer. We also provide evidence that promoter demethylation and close non-coding RNAs (namely, CT-ncRN...

Clinically advanced and metastatic pure mucinous carcinoma of the breast: a c...

Ross(Jeffrey S),Gay(Laurie M),Nozad(Sahar)... Breast Cancer Res Treat 2016-10-14

...PIK3CA (5), BRCA1 (1), TSC2 (1), STK11 (1), AKT3 (1), and ESR1 (1).,Metastatic pmucBC is a distinct form of breast cance...

The cancer genetics and pathology of male breast cancer.

Deb(Siddhartha),Lakhani(Sunil R),Ottini(La... Histopathology 2016-10-20

...PIK3CA mutations and a paucity of TP53 mutations. In general, chromosomal-based changes, in particular regions of gains,...

Genomic analyses reveal FAM84B and the NOTCH pathway are associated with the ...

Cheng(Caixia),Cui(Heyang),Zhang(Ling),Jia(... Gigascience 2016-10-17

...PIK3CA, CDKN2A and their pathways showed no significant difference between stage I and stage III tumors, we identified a...

Responses to the multitargeted MET/ALK/ROS1 inhibitor crizotinib and co-occur...

Jorge(Susan E),Schulman(Sol),Freed(Jason A... Lung Cancer 2016-10-13

...PIK3CA or MET exon 14 skipping mutation with PIK3CA-p.Glu542Lys had significant responses to crizotinib; suggesting that...

Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour g...

Kim(Sun A),Inamura(Kentaro),Yamauchi(Mai),... Br J Cancer 2016-06-06

...PIK3CA, BRAF and KRAS mutations. Mortality according to CDH1 status was assessed using Cox proportional hazards model.,L...

Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative ...

Turner(Tychele N),Hormozdiari(Fereydoun),D... Am J Hum Genet 2016-05-11

...PIK3CA). Our results suggest that the detection of smaller, often multiple CNVs affecting putative regulatory elements m...

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