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Investigating the Inhibitory Effect of Wortmannin in the Hotspot Mutation at ...

Kumar(D Thirumal),Doss(C George Priya) Adv Protein Chem Struct Bio... 2016-08-08

Oncogenic mutations in phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) are the most fre...

Copy number loss of variation_91720 in PIK3CA predicts risk of esophageal squ...

Wu(Yuanyuan),Liu(Xi),Hu(Liwen),Tao(Huanshe... Int J Clin Exp Pathol 2016-10-28

...PIK3CA) and Variation_91733 in sex-determining region Y-box 2 overlapping transcript (SOX2OT) were selected for investig...

Evaluation of AKT phosphorylation and PTEN loss and their correlation with th...

Ma(Yihui),Zhang(Pengyu),Gao(Yi),Fan(Huijie... Int J Clin Exp Pathol 2016-11-01

...PIK3CA was performed by sequencing analysis.,Activation of p-AKT in 12 of 48 (25.0%) and loss expression of PTEN in 15 o...

PIK3CA polymorphisms associated with susceptibility to hepatocellular carcinoma.

Li(Hong-Guang),Liu(Fang-Feng),Zhu(Hua-Qian... Int J Clin Exp Pathol 2016-10-24

Our study was carried out to explore the relationship of PIK3CA rs17849071 and rs17849079 polymorphisms with the suscept...

Mutational profiling of brain metastasis from breast cancer: matched pair ana...

Lee(Ji Yun),Park(Kyunghee),Lim(Sung Hee),K... Oncotarget 2016-10-07

...PIK3CA (14.3%), and KIT (7.1%). We compared BCBM with patient-matched primary BC specimens. There were no significant di...

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclas...

Best(Myron G),Sol(Nik),Kooi(Irsan),Tannous... Cancer Cell 2016-04-04

...PIK3CA tumors were accurately distinguished using surrogate TEP mRNA profiles. Our results indicate that blood platelets...

Particular molecular and ultrastructural aspects in invasive mammary carcinom...

Mihalcea(Corina Elena),Moroşanu(Ana Maria)... Rom J Morphol Embryol 2016-11-07

...PIK3CA, p110α catalytic subunit of PI3K. Our study confirms the high prevalence of PIK3CA mutations in breast cancer. In...

Mutation Profiling of Usual Ductal Hyperplasia of the Breast Reveals Activati...

Jahn(Stephan W),Kashofer(Karl),Thüringer(A... Am J Pathol 2016-05-10

...PIK3CA [6 (43%) of 14], AKT1 [2 (14%) of 14], as well as GNAS, MTOR, PIK3R1, LPHN3, LRP1B, and IGF2R [each 1 (7%) of 14]...

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-g...

Hoffman(Lindsey M),DeWire(Mariko),Ryall(Sc... Acta Neuropathol Commun 2016-10-14

...PIK3CA (n = 2), FGFR1 (n = 2), and MET (n = 1) were also intra-tumorally conserved. ACVR1 was co-mutated with HIST1H3B (...

Obesity and colorectal cancer: molecular features of adipose tissue.

Martinez-Useros(Javier),Garcia-Foncillas(J... J Transl Med 2016-10-10

...PIK3CA)-AKT and protein kinase C pathways. Other product of lipid peroxidation is malondialdehyde (MDA) being able to re...

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