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Investigating the Inhibitory Effect of Wortmannin in the Hotspot Mutation at ...

Kumar(D Thirumal),Doss(C George Priya) Adv Protein Chem Struct Bio... 2016-08-08

Oncogenic mutations in phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) are the most fre...

[Mechanism of TRIM24 to Regulate Resistance of Gefitinib in NSCLC cells].

Li(Haiying),Wang(Qingling),Bao(Haijun),Zha... Zhongguo Fei Ai Za Zhi 2016-10-05

...PIK3CA related AKT signal path in A549 cell.,TRIM24 could regulate required resistance to Gefitinib via Akt pathway in N...

Microglandular adenosis associated with triple-negative breast cancer is a ne...

Guerini-Rocco(Elena),Piscuoglio(Salvatore)... J Pathol 2016-08-01

...PIK3CA, and INPP4B) and tyrosine kinase receptor signalling-related genes (eg ERBB3 and FGFR2) were identified. At diagn...

Clinicopathologic Significance of HNF-1β, AIRD1A, and PIK3CA Expression in Ov...

Ye(Shuang),Yang(Jiaxin),You(Yan),Cao(Dongy... Medicine (Baltimore) 2016-07-15

...PIK3CA) mutations are common genetic changes in ovarian CCC. Hepatocyte nuclear factor-1β (HNF-1β) expression has been p...

Malignancy of Cancers and Synthetic Lethal Interactions Associated With Mutat...

Wang(Xiaosheng),Zhang(Yue),Han(Ze-Guang),H... Medicine (Baltimore) 2016-07-21

...PIK3CA, and TP53 by comparison of their gene phenotype values in cancer cell lines with the relevant mutations and wild-...

Highlights from the 38th SABCS annual meeting, 8th - 12th December 2015, San ...

Cairns(Linda),Curigliano(Giuseppe) Ecancermedicalscience 2016-02-25

...PIK3CA, chemotherapy combinations for HER-2-positive disease, long-term outcomes of different surgeries for early-stage ...

Responses to the multitargeted MET/ALK/ROS1 inhibitor crizotinib and co-occur...

Jorge(Susan E),Schulman(Sol),Freed(Jason A... Lung Cancer 2016-10-13

...PIK3CA or MET exon 14 skipping mutation with PIK3CA-p.Glu542Lys had significant responses to crizotinib; suggesting that...

Genomic analysis identifies new drivers and progression pathways in skin basa...

Bonilla(Ximena),Parmentier(Laurent),King(B... Nat Genet 2016-08-12

...PIK3CA (2%), and NRAS, KRAS or HRAS (2%), and loss-of-function and deleterious missense mutations were present in PTPN14...

MYC functions are specific in biological subtypes of breast cancer and confer...

Green(Andrew R),Aleskandarany(Mohammed A),... Br J Cancer 2016-08-24

...PIK3CA (P=0.009) and Ki67 (P<0.001). In contrast, in basal-like tumours, c-MYC showed positive association with Cyclin E...

miR-203 inhibits cell proliferation and promotes cisplatin induced cell death...

Lin(Jiong),Lin(Yao),Fan(Li),Kuang(Wei),Zhe... Biochem Biophys Res Commun 2016-09-06

...PIK3CA expression and Akt activation. Furthermore, miR-203 repressed PIK3CA expression through targeting the 3'UTR. Rest...

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