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TP53 BRCA1 CRISPR single-cell cancer

Abba(Martin C),Gong(Ting),Lu(Yue),Lee(Jaeh... Cancer Res 2016-01-04

...PIK3CA (21% of cases), TP53 (17%), GATA3 (7%), MLL3 (7%) and single cases of mutations affecting CDH1, MAP2K4, TBX3, NF1...

Onesti(Concetta Elisa),Vicier(Cécile),Andr... Breast 2016-08-23

...PIK3CA mutations, FGFR1 amplifications, AKT1 mutations, EGFR amplifications and ERBB2 mutations. Beside driver identific...

Harms(Paul William),Vats(Pankaj),Verhaegen... Cancer Res 2016-01-04

...PIK3CA, we discovered activating mutations of oncogenes, including HRAS and loss-of-function mutations in PRUNE2 and NOT...

Remy(Elisabeth),Rebouissou(Sandra),Chaouiy... Cancer Res 2016-01-30

...PIK3CA mutation or p21CIP deletion would greatly favor invasiveness. Furthermore, the model sheds light on the temporal ...

Ward(Douglas G),Baxter(Laura),Gordon(Nahee... PLoS One 2016-07-15

...PIK3CA, TP53, HRAS, KDM6A and RXRA which are frequently mutated in bladder cancer. The PCR products were barcoded, poole...

Zhang(Quan),Sun(Tianyu),Kang(Poming),Qian(... Cancer Chemother Pharmacol 2016-07-26

The assessment of single gene such as ERCC1, TYMS, RRM1, TUBB3, EGFR, KRAS, BRAF, PIK3CA, ALK, and ROS1 is now widely ap...

Martinez-Useros(Javier),Garcia-Foncillas(J... J Transl Med 2016-10-10

...PIK3CA)-AKT and protein kinase C pathways. Other product of lipid peroxidation is malondialdehyde (MDA) being able to re...

Qu(Liujing),Li(Ge),Xia(Dan),Hongdu(Beiqi),... Biochem Biophys Res Commun 2016-06-14

...PIK3CA/AKT-MTOR) signaling. These data underscore the importance of PRKCI in the regulation of autophagy. Moreover, the ...

Hu(Hai),Juvekar(Ashish),Lyssiotis(Costas A... Cell 2016-06-09

...PIK3CA mutations have the opposite effect. These results point toward a master regulatory function of PI3K that integrat...

Forest(Fabien),Yvorel(Violaine),Karpathiou... Hum Pathol 2016-06-06

...PIK3CA genes was established. Of 18 PSCGCs with adenocarcinomatous or "undifferentiated" carcinoma differentiation, 8 we...

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