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TP53 BRCA1 CRISPR single-cell cancer

Remy(Elisabeth),Rebouissou(Sandra),Chaouiy... Cancer Res 2016-01-30

...PIK3CA mutation or p21CIP deletion would greatly favor invasiveness. Furthermore, the model sheds light on the temporal ...

Stahler(A),Heinemann(V),Giessen-Jung(C),Cr... Int J Cancer 2016-06-01

...PIK3CA-mutations (by pyrosequencing) were assessed. Tumors of 208 mCRC patients receiving 5-fluorouracil/leucovorin plus...

Kleist(Britta),Kempa(Marcel),Meurer(Thuja)... J Clin Pathol 2016-06-29

...PIK3CA-wild type status is a known prerequisite for epidermal growth factor receptor (EGFR) inhibitor therapy. This stud...

Mackenzie(Robertson),Kommoss(Stefan),Winte... BMC Cancer 2016-02-04

...PIK3CA, PTEN, BRAF, FGFR2, STK11, CTNNB1, SRC, SMAD4, GNA11 and ERBB2. KRAS mutations remain the most frequently observe...

Mohan(Suresh),Vander Broek(Robert),Shah(Su... Clin Cancer Res 2016-06-07

...PIK3CA, and sensitivity correlated with increased phospho-AKT(T308/S473). In resistant UMSCC-1 and -46 models, PF-384 in...

Chen(Shu-Jen),Liu(Hsuan),Liao(Chun-Ta),Hua... Oncotarget 2016-05-24

...PIK3CA, CDKN2A, HRAS and BRAF were the most frequently mutated genes. Mutations in 14 genes were found to predict DFS. A...

Janku(Filip),Angenendt(Philipp),Tsimberido... Oncotarget 2016-03-25

...PIK3CA using the BEAMing method and results were compared to mutation analysis of archival tumor tissue from a CLIA-cert...

Jang(Jin Sung),Lee(Adam),Li(Jun),Liyanage(... Sci Rep 2016-03-24

...PIK3CA (3 cases, 3%), and ERBB2 (4 cases, 5%). In addition to ALK fusions identified by IHC/FISH in four cases, two prev...

Rusan(Maria),Li(Yvonne Y),Hammerman(Peter ... Clin Cancer Res 2016-03-31

...PIK3CA mutations (and aberrations in other members of the PI3K pathway), alterations in receptor tyrosine kinases (prima...

Arqués(Oriol),Chicote(Irene),Puig(Isabel),... Clin Cancer Res 2016-10-25

...PIK3CA) did not.,High nuclear β-catenin content independently predicts resistance to PI3K and AKT inhibitors. Combined t...

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