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Hotspot mutation panel testing reveals clonal evolution in a study of 265 pai...

Goswami(Rashmi S),Patel(Keyur P),Singh(Raj... Clin Cancer Res 2016-02-22

...PIK3CA and SMAD4. PIK3CA mutations were more often associated with metastasis in colon carcinoma samples.,Clinical NGS h...

A retrospective observational study of clinicopathological features of KRAS, ...

Kawazoe(Akihito),Shitara(Kohei),Fukuoka(Sh... BMC Cancer 2016-01-08

...PIK3CA mutations on the efficacy of anti-EGFR therapy remains controversial. Little is known about the frequencies and c...

Successful control of heavily pretreated metastatic gastric cancer with the m...

Park(Ji Hyun),Ryu(Min-Hee),Park(Young Soo)... BMC Cancer 2016-01-22

...PIK3CA hotspot mutation and pS6 overexpression in the primary tumor. After two cycles of everolimus re-treatment, the ov...

Microsatellite instability and mutations in BRAF and KRAS are significant pre...

Birgisson(Helgi),Edlund(Karolina),Wallin(U... BMC Cancer 2016-01-22

...PIK3CA mutations, microsatellite instability (MSI), and average DNA copy number, in connection with tumour dissemination...

CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wn...

Ye(Hua),Zhang(Jing),Wang(Jun),Gao(Yanyan),... Arthritis Res Ther 2016-01-08

...PIK3CA) were involved in STAT3 (signal transducer and activator of transcription 3) signaling, and three genes (CBL, KLF...

Prospective comprehensive genomic profiling of advanced gastric carcinoma cas...

Ali(Siraj M),Sanford(Eric M),Klempner(Samu... Oncologist 2016-04-11

...PIK3CA (8.6%), MLL2 (6.9%), FGFR2 (6.0%), and MET (6.0%). Receptor tyrosine kinase genomic alterations were detected in ...

PI3K inhibition results in enhanced estrogen receptor function and dependence...

Bosch(Ana),Li(Zhiqiang),Bergamaschi(Anna),... Sci Transl Med 2016-01-12

Activating mutations of PIK3CA are the most frequent genomic alterations in estrogen receptor (ER)-positive breast tumor...

Clonal status of actionable driver events and the timing of mutational proces...

McGranahan(Nicholas),Favero(Francesco),de ... Sci Transl Med 2016-01-12

...PIK3CA (E545K), EGFR (L858R), and KRAS (G12D), which may compromise the efficacy of targeted therapy approaches. More th...

Inhibition of the phosphoinositide 3-kinase pathway for the treatment of pati...

Moulder(S),Helgason(T),Janku(F),Wheler(J),... Ann Oncol 2016-04-05

...PIK3CA/Akt/mTOR axis: PIK3CA mutation = 2; PTEN loss = 1; NF2 aberration = 1.,DAT has activity in MpBCs including comple...

The repertoire of somatic genetic alterations of acinic cell carcinomas of th...

Guerini-Rocco(Elena),Hodi(Zsolt),Piscuogli... J Pathol 2016-06-06

...PIK3CA, MTOR, CTNNB1, BRCA1, ERBB4, ERBB3, INPP4B, and FGFR2. Copy number alteration analysis revealed complex patterns ...

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