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GARD: Genomic Data-Based Drug Repurposing in Head and Neck Cancer with Large ...

Tanikella(P),Nenad(W),Courtine(C),Dai(Y),D... Cancers (Basel) 2026-02-26

...PIK3CA, SOX2, TP53, EIF4G1, TLR7, CLDN1, PRKCI, and EPHA2. Further expansion through the PPI network identified other ta...

Integrated Molecular and Functional Characterization of Cervical Small-Cell N...

Sohel(HI),Zahan(UF),Ishikawa(M),Kanno(K),Y... Int J Mol Sci 2026-03-04

...PIK3CA hotspot mutation (p.E542K) and conserved oncogenic copy-number gains of PIK3CA, TERT, and MYC, as well as copy nu...

GPS1 Exon 9 Mutations Represent a Rare Genetic Event in Penile Squamous Cell ...

Tögel(L),Elsner(F),Wendler(O),Giedl(J),Gai... Int J Mol Sci 2026-03-07

...PIK3CA, NOTCH1, and FAT1 as frequently altered genes with potential roles in penile oncogenesis. In addition, recurrent ...

Exploring the Mechanism of Selenium-Biofortified Polygonatum Kingianum in Alz...

Jia(Z),Xiao(Q),Shi(G),Wang(X) Comb Chem High Throughput S... 2026-03-12

...PIK3CA, HSP90AA1, STAT3] were enriched in PI3K/Akt signaling and other AD-related pathways [FDR < 0.01]. Se-PK likely mo...

Active Components and Potential Mechanism of Redujing Oral Liquid for Treatin...

Yao(Y),Cui(H),Li(X),Kong(W) Comb Chem High Throughput S... 2026-03-11

...PIK3CA, and AKT1. Molecular docking and dynamics simulations showed a strong binding affinity between baicalein and PIK3...

Multidisciplinary management of pediatric head and neck lymphatic malformatio...

Singh(S),Chun(RH),Carlberg(VM),Schloemer(N... Int J Pediatr Otorhinolaryngol 2026-05-00

...PIK3CA variants. Ten patients (16.9%) experienced ≥1 complication. Procedure-level complications occurred after 5/86 scl...

Sanhuang xiexin decoction ameliorates gastric ulcers by activating EGFR/PI3K/...

Liu(X),Wu(X),Wang(H),Fang(C),Fan(B),Wang(X... J Ethnopharmacol 2026-06-28

...PIK3CA critical targets. SHXD could upregulate the core target EGFR, subsequently triggering PI3K/AKT pathway, thereby e...

Persistent PI3K-AKT signaling fortifies cellular defense against oxidative st...

Xie(X),Wang(S),Zeng(W),Long(X),Zheng(D),Ye... Cell Mol Biol Lett 2026-03-14

...PIK3CA-E542K in HeLa cells. RESULTS: Cancer cells with constitutive PI3K activation exhibited high resistance to oxidati...

Early modulatory effects of Porphyromonas gingivalis and Lactobacillus saliva...

Samia(U),Vlajic Tovilovic(T),Pecinar(I),Ra... Mol Biol Rep 2026-03-16

...PIK3CA, AKT, mTOR, ALOX5, VEGF, COX2, HEY1, JAGGED1) via qPCR. Complementary assays included Annexin V, scratch-wound he...

Molecular analysis of a gliosarcoma with distinct oligodendroglioma and sarco...

Sasaki(S),Sakaguchi(M),Takeda(M),Nitta(Y),... Brain Tumor Pathol 2026-03-15

...PIK3CA p.C90G mutations together with 1p/19q codeletion, and subsequently acquired additional mutations and chromosomal ...

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