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Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its as...

Wei(Leizhen),Lan(Li),Hong(Zehui),Yasui(Aki... Mol Cell Biol 2009-01-09

...BRCA1 at DSBs produced by laser microirradiation. The amino (N)- and carboxyl (C)-terminal fragments of BRCA1 accumulate...

A PP1-binding motif present in BRCA1 plays a role in its DNA repair function.

Yu(Young-Mi),Pace(Serena M),Allen(Susan R)... Int J Biol Sci 2008-12-11

...BRCA1 demonstrated that mutation of the PP1-binding motif affected BRCA1 redistribution in response to DNA damage. BRCA1...

Targeting the Akt/mTOR pathway in Brca1-deficient cancers.

Xiang(T),Jia(Y),Sherris(D),Li(S),Wang(H),L... Oncogene 2011-08-01

...Brca1 expression or mutations of the Brca1 gene activate the Akt oncogenic pathway. To further investigate the role of B...

The carboxyl-terminal of BRCA1 is required for subnuclear assembly of RAD51 a...

Zhou(Chenyi),Huang(Peng),Liu(Jinsong) Biochem Biophys Res Commun 2005-11-01

...BRCA1 in this process remains to be characterized. The purpose of the study was therefore to determine the role of BRCA1...

BRCA1 interacts with poly(A)-binding protein: implication of BRCA1 in transla...

Dizin(Eva),Gressier(Céline),Magnard(Clémen... J Biol Chem 2006-11-06

...BRCA1. To understand the biological function of the BRCA1-PABP complex, we sought to determine whether BRCA1 is a modula...

BRCA1-Dependent Translational Regulation in Breast Cancer Cells.

Dacheux(Estelle),Vincent(Anne),Nazaret(Nic... PLoS One 0000-00-00

...BRCA1. The BRCA1-dependent translation of these species of mRNAs therefore uncovers a novel mechanism through which BRCA...

Insights into the targeted elimination of BRCA1-defective cancer stem cells.

Somasundaram(Veena),Srinivas(Priya) Med Res Rev 2013-05-09

...BRCA1-defective tumor progression, phenotype of BRCA1-defective cancers, role of BRCA1 in other cancers and finally at w...

BRCA1 protein level is not affected by peptide growth factors in MCF10A cell ...

Aprelikova(O),Kuthiala(A),Bessho(M),Ethier... Oncogene 1997-01-13

...BRCA1. The antibody recognizes a specific BRCA1 protein doublet of about 220 kD. The majority of BRCA1 protein is locali...

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA h...

Anderson(S F),Schlegel(B P),Nakajima(T),Wo... Nat Genet 1998-07-31

...BRCA1 to the holoenzyme complex. The region of BRCA1 which interacts with RHA and, thus, the holoenzyme complex, corresp...

A novel domain of BRCA1 interacts with p53 in breast cancer cells.

Buck(Martina) Cancer Lett 2008-10-14

...BRCA1 (amino acids 224-500) and the second BRCT domain of the BRCA1 C-terminus may interact with p53, quantitative bioph...

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