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Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma...

Sholl(Lynette M),Aisner(Dara L),Varella-Ga... J Thorac Oncol 2016-03-21

...PIK3CA) using SNaPshot, mass spectrometry, Sanger sequencing+/- peptide nucleic acid and/or sizing assays, along with an...

Deciphering the impact of somatic mutations in exon 20 and exon 9 of PIK3CA g...

Sudhakar(N),Priya Doss(C George),Thirumal ... J Biomol Struct Dyn 2016-10-07

...PIK3CA gene in South Indian population. Genomic DNA was isolated and amplified for PIK3CA gene, followed by direct seque...

PIK3CA Pathway Mutations Predictive of Poor Response Following Standard Radio...

de la Rochefordiere(Anne),Kamal(Maud),Floq... Clin Cancer Res 2016-02-22

...PIK3CA, KRAS, and STK11 mutations were observed in 22%, 4%, and 2% of patients, respectively. No tumor with a PI3K pathw...

Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squ...

Cohen(Daniel N),Lawson(Steven K),Shaver(Aa... Clin Cancer Res 2016-02-22

...PIK3CA, CKIT, ALK, and EGFR mutations also detected.,We examined clinical, histopathologic, viral, and genetic parameter...

No impact of passive smoke on the somatic profile of lung cancers in never-sm...

Couraud(Sébastien),Debieuvre(Didier),Morea... Eur Respir J 2016-04-06

...PIK3CA mutations are typically observed among smokers. There is still debate surrounding whether never-smokers exposed t...

Genomic alterations in head and neck squamous cell carcinoma determined by ca...

Chung(C H),Guthrie(V B),Masica(D L),Tokhei... Ann Oncol 2016-05-13

...PIK3CA and PTEN in HPV-positive tumors and TP53 and CDKN2A/B in HPV-negative tumors. In the pathway analysis, the PI3K p...

Why increased nuchal translucency is associated with congenital heart disease...

Burger(Nicole B),Bekker(Mireille N),de Gro... Prenat Diagn 2016-02-24

...Pik3ca); Podoplanin; Prospero-related homeobox 1 (Prox1); T-box 1 (Tbx1); Tyrosine kinase with immunoglobulin-like and e...

Refining prognosis and identifying targetable pathways for high-risk endometr...

Stelloo(Ellen),Bosse(Tjalling),Nout(Remi A... Mod Pathol 2016-03-25

...PIK3CA, PPP2R1A, and PTEN) and protein expression of ER, PR, PTEN, and ARID1a was analyzed. Rates of distant metastasis,...

AKT1 E17K in Colorectal Carcinoma Is Associated with BRAF V600E but Not MSI-H...

Hechtman(Jaclyn F),Sadowska(Justyna),Huse(... Mol Cancer Res 2016-03-18

...PIK3CA-mutated colorectal carcinoma are described in detail. Interestingly, in comparison with PIK3CA mutants, AKT1 E17K...

Molecular landscape of pancreatic cancer: implications for current clinical t...

Heestand(Gregory M),Kurzrock(Razelle) Oncotarget 2016-01-12

...PIK3CA, and BRAF. In the era of tumor profiling, these aberrations may provide an opportunity for new therapeutic approa...

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