...PIK3CA (55 %, 14 %, and 9 %, respectively). The mutation rates were similar between responders and non-responders (avera...
...PIK3CA(H1047R), an oncogenic mutant linked to ERα(+)/luminal breast cancer in humans, induced metastatic luminal B-like ...
...PIK3CA mutations; and LINE-1 methylation. We adjusted the two-sided α level to 0.012 for multiple hypothesis testing. Tu...
...PIK3CA/PIK3R1 mutation did not correlate with clinical activity, whereas RAS/RAF pathway mutations did segregate with re...
...PIK3CA mutational status. Tolerance, efficacy, and pharmacodynamic evaluation of target modulation were evaluated in res...
...PIK3CA mutations are amongst the most promising markers.,Neoadjuvant treatment should be considered for all patients wit...
...PIK3CA. Although clustering of missense mutations is often regarded as a hallmark of oncoproteins, we observed that a nu...
...PIK3CA mutations (20.0% v 33.9%; P = .008). Intratumor genetic heterogeneity was greater in African American than white ...
...PIK3CA, FBXW7, SMAD4, BRAF and NRAS genes was determined for 204 CRC samples by targeted massive parallel sequencing. Cl...
...PIK3CA, and KRAS. All these mutations were confirmed as somatic and are previously known mutations. In summary, mutation...
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