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Associations of TILs and genomic alterations in HER2+ early breast cancer.

Lu(S),Huang(J),Gu(Y),Wang(C),Shen(K),Fei(X... Endocr Relat Cancer 2026-08-01

...PIK3CA mutations conferred a significant DFS advantage. Integrating TIL level with PIK3CA or BRCA2 mutational status yie...

Primary Tumor Genomics and Patterns of Distant Recurrence in Resected Gastric...

Coffey(MR),Xu(J),Atri(P),Lambert(KE),Shima... JAMA Surg 2026-08-05

...PIK3CA (HR, 2.15; 95% CI, 1.25-3.69; P = .006) were independently associated with worse disease-free survival. Tumors of...

Clinical Utility of Molecular Testing in Ameloblastoma: A Systematic Review w...

Ardila(CM),Pineda-Vélez(E),Díaz-Laclaustra... Head Neck Pathol 2026-08-05

...PIK3CA, EGFR, and ROS1 were reported, particularly in selected or BRAF-wild-type tumors. Exploratory meta-analysis of 19...

A multi-model prediction of a stage-specific prognosis for colorectal cancer ...

Supriya(K),Anitha(A) Front Artif Intell None

...PIK3CA, and SMAD4 are observed in the collected samples, contributing to CRC. An effort has been made in the proposed wo...

A pontine-specific niche supports de novo gliomagenesis.

Pathak(A),Wells(GB),Bankaitis(VA),Xie(Z) Cell Rep 2026-08-05

...Pik3ca mutations (which co-occur with H3.1K27M in human DIPGs) induces rapid gliomagenesis specifically in the pons. We ...

Predictive value of peripheral blood cell-free DNA breast cancer gene mutatio...

Lyu(G),Duan(H),Sheng(X),Liu(L),Luo(J) Front Genet None

...PIK3CA, etc.), and a composite Gene Mutation Score (GMS) were analyzed. Multivariate logistic regression analysis was us...

Safety analyses of the INAVO120 randomised phase III trial of inavolisib or p...

Im(SA),Kalinsky(K),Jhaveri(KL),Loibl(S),Tu... ESMO Open 2026-06-00

...PIK3CA-mutated, hormone receptor-positive, HER2-negative, endocrine-resistant advanced breast cancer. We provide compreh...

Effect of prior anti-EGFR therapy and baseline ctDNA profiling on the efficac...

Matsubara(Y),Wakabayashi(M),Okamoto(W),Kat... ESMO Open 2026-06-00

...PIK3CA mutations; EGFR ectodomain mutation; or MET amplification. Clinical outcomes with PER + TRA were analyzed in pati...

Somatic PIK3CA and PTEN mutations with endothelial PI3K/AKT/mTOR activation i...

Hata(Y),Tanaka(R),Ichimata(S),Kuroda(S),Ni... J Neuropathol Exp Neurol 2026-07-25

...PIK3CA mutations, including one case with a concurrent PTEN alteration. Histologically, both lesions demonstrated typica...

DHODH is a synthetic lethal target in PIK3CA-mutant colorectal cancer.

Liang(J),Liu(X),Ni(Z),Zhang(S),He(X),Wang(... Cell Rep 2026-07-24

...PIK3CA-mutant colorectal cancer (CRC). DHODH sustains WDR77 O-GlcNAcylation and protein stability by promoting the gener...

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