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Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of…

Mazières(J),Tillement(V),Allal(C),Clanet(C),… Exp Cell Res 2005-04-01

...RhoB-GG, but not by RhoB-F, providing further support for the opposing role of RhoB-F and RhoB-GG in Ras malignant trans...

Farnesyltransferase inhibitors alter the prenylation and growth-stimulating fun…

Lebowitz(PF),Casey(PJ),Prendergast(GC),Thiss… J Biol Chem 1997-06-20

...RhoB in cells. This issue is complex because farnesylated and geranylgeranylated forms of RhoB (RhoB-F and RhoB-GG) both...

RhoB is regulated by hypoxia and modulates metastasis in breast cancer.

Ju(JA),Godet(I),DiGiacomo(JW),Gilkes(DM) Cancer Rep (Hoboken) 2020-00-00

...RhoB mRNA and protein expression resulting in increased levels of activated RhoB. Both loss of RhoB and gain of RhoB exp...

Critical functions of RhoB in support of glioblastoma tumorigenesis.

Ma(Y),Gong(Y),Cheng(Z),Loganathan(S),Kao(C),… Neuro Oncol 2015-04-00

...RhoB or a constitutively active mutant (RhoB-V14) did not significantly affect cell growth, which suggests that RhoB is ...

RhoB plays a central role in hyperosmolarity-induced cell shrinkage in renal ce…

Centrone(M),Saltarella(I),D'Agostino(M),Rani… J Cell Physiol 2024-09-00

...RhoB can be subjected to either geranylgeranylation (RhoB-GG) or farnesylation (RhoB-F), making that the only target of ...

Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation …

Wherlock(M),Gampel(A),Futter(C),Mellor(H) J Cell Sci 2004-07-01

...RhoB exists as two prenylated forms in cells: geranylgeranylated RhoB (RhoB-GG) and farnesylated RhoB (RhoB-F). Here we ...

RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic com…

Bravo-Nuevo(A),Sugimoto(H),Iyer(S),Fallon(Z)… Am J Pathol 2011-01-00

...RhoB dependent. We induced β-cell depletion in RhoB(+/+), RhoB(+/-), and RhoB(-/-) mice with streptozotocin (STZ). Diabe...

Role of RHOB in the antiproliferative effect of glucocorticoid receptor on macr…

Wang(X),Chen(Y),Wang(Y),Zhu(X),Ma(Y),Zhang(S… J Endocrinol 2009-01-00

...Rhob expression vector (Rhob-wt) or constitutively activated Rhob plasmid (Rhob-V14) resulted in decreased proliferation...

RhoB is involved in lipopolysaccharide-induced inflammation in mouse in vivo an…

Wang(XH),Wang(Y),Diao(F),Lu(J) J Physiol Biochem 2013-06-00

...RhoB and inflammation. In this study, the mRNA and protein levels of RhoB were induced by lipopolysaccharide (LPS) in RA...

Ras-related GTPase RhoB forces alkylation-induced apoptotic cell death.

Fritz(G),Kaina(B) Biochem Biophys Res Commun 2000-02-24

...RhoB in cellular defense, cells stably overexpressing wild-type RhoB protein were generated. Overexpression of RhoB rend...

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