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Astragali radix Against Colorectal Cancer: Network Pharmacology, Molecular Do...

Li(Z),Guo(J),Gui(M),Xu(J),Zhao(J),Zhang(X)... Phytother Res 2026-06-00

...PIK3CA, and AKT1. Enrichment analysis revealed that these targets are primarily involved in the regulation of the PI3K-A...

Loss of PIK3CA Allows In Vitro Growth but Not In Vivo Progression of KRAS Mut...

Booth(AL),Caso(G),Rosati(B),Jiang(YP),Zong... Cells 2026-03-12

...PIK3CA for tumor growth both in vitro and in vivo. We first generated a "KPA" cell line by genetically deleting Pik3ca f...

Cell-Free DNA as Biomarker in Oral Squamous Cell Carcinoma: Dynamics, Mutatio...

Veiga(P),Barroso(L),Pires(LM),Mano(C),Cara... Cells 2026-03-23

...PIK3CA, KRAS, APC, and FBXW7. Urine cfDNA also captured several mutations absent from plasma or tissue, supporting its c...

The Effect of Viniferin on Liver Cancer: Research Based on Network Pharmacolo...

Maungchanburi(S),Wongmek(O),Baitahay(P),Sa... Med Sci (Basel) 2026-03-11

...PIK3CA. Enrichment analysis confirmed their involvement in critical oncogenic pathways. Molecular docking showed strong ...

Biomarkers in Colorectal Cancer: Clinically Relevant Diagnostic and Prognosti...

Whitmer(R),Sepulveda(J),Gandhi(J),Puri(I),... J Pers Med 2026-02-28

...PIK3CA and BRAF, provide valuable insights into tumor biology, therapeutic resistance, and response to targeted therapie...

Age-related genomic characterization and therapeutic targets in Chinese breas...

Sui(XY),Song(XQ),Liu(XY),Shao(ZM),Hu(X),Ch... BMC Med 2026-03-27

...PIK3CA, FOXA1, and TBX3 mutations were more prevalent in elderly patients. By leveraging the aforementioned mutational c...

Age-Associated Genetic Variations in Breast Cancer: Somatic Mutations and Co-...

Ekinci(B),Orenay-Boyacioglu(S),Erdogdu(IH)... Biomedicines 2026-02-25

...PIK3CA, PTEN, RAD50, BLM, NF1, AR, BRCA2, and KMT2C. Notably, PIK3CA mutations were significantly more frequent in geria...

Anthracycline-Free Neoadjuvant Pertuzumab-Trastuzumab-Taxane in Patients with...

Irelli(A),Sidoni(T),Pavese(F),Rotondaro(S)... Biomedicines 2026-03-20

...PIK3CA mutations with anthracycline-free regimens remains unclear. Methods: We retrospectively analyzed 56 patients with...

A Study on the Mechanism of Acetyl Tributyl Citrate-Induced Infertility Toxic...

Sun(X),Chen(P),Han(Y),Du(Y),Sun(S),Miu(J),... Int J Mol Sci 2026-03-23

...PIK3CA, CASP3, HRAS-and four core targets for icariin treatment-IL6, TNF, STAT3, and INS. Gene ontology (GO) and Kyoto E...

Pan-Cancer Targeted Sequencing Reveals Genomic Heterogeneity and Prognostic S...

Ugrinovski(D),Saidi(S),Stankov(V),Ambardji... Cancers (Basel) 2026-03-22

...PIK3CA (≈20%), consistent with established molecular pathways in UBC. Less frequent but potentially actionable alteratio...

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