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Genetic dynamics in untreated chronic lymphocytic leukemia patients with eith...

样本量:52 物种:Homo sapiens 类型:genotyping by array 2019年11月5日

...PIK3CA, POT1, SF3B1, TP53, XPO1 and ZMYM3, which were previously identified as mutated in CLL studies.

Genomic characterization of intrinsic and acquired resistance to cetuximab in...

样本量:31 物种:Homo sapiens 类型:genotyping by array 2019年9月21日

...PIK3CA E542K, and FGFR1 or ERBB2 amplifications. The comparison between baseline and acquired-resistant tumours revealed...

Pathways regulated by oncogenic PTEN/PI3K/AKT signalling in NSCLC

样本量:9 物种:Homo sapiens 类型:transcription profiling by array 2016年12月1日

...PIK3CA (PIK3CA-E545K) or that are silenced for PTEN. For each sample, 500 ng of total RNA were used to synthesize biotin...

Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas...

样本量:121 物种:Homo sapiens 类型:transcription profiling by array 2016年8月21日

...PIK3CA and SMO, we also report somatic mutations in AKT3, PIK3R1, PRKAR1A, and SUFU in meningiomas. Our results identify...

Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas...

样本量:19 物种:Homo sapiens 类型:RNA-seq of coding RNA 2016年8月21日

...PIK3CA and SMO, we also report somatic mutations in AKT3, PIK3R1, PRKAR1A, and SUFU in meningiomas. Our results identify...

Integrated molecular pathway analysis informs a synergistic combination thera...

样本量:190 物种:Homo sapiens 类型:transcription profiling by array 2016年8月21日

...PIK3CA, PTEN, or INPP4B; when including upstream kinases HER2 and EGFR, 75 % of cases had one or more aberration includi...

AKT Isoform Specificity Downstream of PIK3CA Mutation Impacts Estradiol and P...

样本量:24 物种:Homo sapiens 类型:transcription profiling by array 2016年8月10日

Background: PIK3CA mutations are observed in >30% of breast cancers, which are more common in estrogen receptor (ERα)-po...

Intra-individual genomic heterogeneity of ovarian serous adenocarcinoma [Agil...

样本量:58 物种:Homo sapiens 类型:comparative genomic hybridization by ... 2016年8月9日

...PIK3CA, and RB1 were also identified. Of note, the mutations detected in ascitic cancer cells represented 92.3-100% of o...

Intra-individual tumoral heterogeneity of ovarian serous adenocarcinomas [Ill...

样本量:16 物种:Homo sapiens 类型:methylation profiling by array 2016年8月9日

...PIK3CA, and RB1 were also identified. Of note, the mutations detected in ascitic cancer cells represented 92.3-100% of o...

Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberr...

样本量:9 物种:Homo sapiens 类型:transcription profiling by array 2016年6月13日

...PIK3CA) and/or mutations of AKT1 itself. However, whereas the effects of AKT activation on mRNAs and proteins in the cel...

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