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PMID: 985808 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Induction of interferon in ovine and human lymphocyte cultures by mycoplasmas.

Infection and immunity ·Vol. 14 ·No. 1 ·1976-07-00 ·Pages 88-94

Cole BC, Overall JC, Lombardi PS, Glasgow LA

Abstract

Mycoplasma pneumoniae, Acholeplasma laidlawii, M. arthritidis, and M. pulmonis were shown to induce interferon in the lymphocyte fraction of ovine peripheral blood leukocytes, but not in the polymorphonuclear leukocyte fraction. Human peripheral blood lymphocytes produced significant levels of interferon in response to infection with M. pneumoniae and M. synoviae. The antiviral substance induced by the mycoplasmas in human lymphocytes was characterized as interferon by the usual criteria.

MeSH Terms
Acholeplasma laidlawii Animals Cells, Cultured Humans Interferons/biosynthesis Lymphocytes/metabolism Mycoplasma Neutrophils/metabolism Sheep Species Specificity
Chemicals
Interferons
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cole B C
Overall J C
Lombardi P S
Glasgow L A
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26 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.14.1.88-94.1976
Published
1976-07-00
Pages
88-94
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC420848
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.14.1.88-94.1976 PMC Full Text View journal details
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