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PMID: 4356073 Published · ppublish English Journal Article

Mycoplasma-associated induction of interferon in ovine leukocytes.

Infection and immunity ·Vol. 8 ·No. 5 ·1973-11-00 ·Pages 796-803

Rinaldo CR, Overall JC, Cole BC, Glasgow LA

Abstract

A mycoplasmal species, Acholeplasma laidlawii, isolated as a contaminant from a fetal lamb kidney cell line, was shown to be associated with the induction of interferon in cultures of ovine peripheral blood leukocytes. Broth cultures of the mycoplasma induced between 20 and 230 U of interferon per ml in leukocytes from two adult ewes. The amount of interferon produced correlated with the inoculum size of mycoplasma. Interferon production was associated with replication of the mycoplasma in the leukocyte cultures. Interferon was not induced by sterile mycoplasmal broth, a cell-free filtrate of the mycoplasmal cultures, or heat-inactivated mycoplasmas. The antiviral substance was characterized as interferon by the usual criteria.

MeSH Terms
Animals Cells, Cultured Chick Embryo Cricetinae Culture Techniques Fetus Interferon Inducers Interferons/analysis Kidney/microbiology L Cells Leukocytes/immunology Mycoplasma/growth & development,immunology Sheep Vesicular stomatitis Indiana virus/immunology Viral Interference Viral Plaque Assay
Chemicals
Interferon Inducers Interferons
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rinaldo C R
Overall J C
Cole B C
Glasgow L A
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.8.5.796-803.1973
Published
1973-11-00
Pages
796-803
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422930
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.8.5.796-803.1973 PMC Full Text View journal details
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