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PMID: 9854075 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

New York 1 and Sin Nombre viruses are serotypically distinct viruses associated with hantavirus pulmonary syndrome.

Journal of clinical microbiology ·Vol. 37 ·No. 1 ·1999-01-00 ·Pages 122-6

Gavrilovskaya I, LaMonica R, Fay ME, Hjelle B, Schmaljohn C, Shaw R, Mackow ER

Abstract

New York 1 virus (NY-1) and Sin Nombre virus (SN) are associated with hantavirus pulmonary syndrome (HPS). NY-1 and SN are derived from unique mammalian hosts and geographic locations but have similar G1 and G2 surface proteins (93 and 97% identical, respectively). Focus reduction neutralization assays were used to define the serotypic relationship between NY-1 and SN. Sera from NY-1-positive Peromyscus leucopus neutralized NY-1 and SN at titers of >/=1/3,200 and </=1/400, respectively (n = 12). Conversely, SN-specific rodent sera neutralized NY-1 and SN at titers of <1/400 and 1/6,400, respectively (n = 13). Acute-phase serum from a New York HPS patient neutralized NY-1 (1/640) but not SN (<1/20), while sera from HPS patients from the southwestern United States had 4- to >16-fold-lower neutralizing titers to NY-1 than to SN. Reference sera to Hantaan, Seoul, and Prospect Hill viruses also failed to neutralize NY-1. These results indicate that SN and NY-1 define unique hantavirus serotypes and implicate the presence of additional HPS-associated hantavirus serotypes in the Americas.

MeSH Terms
Animals Antigens, Viral/blood Chlorocebus aethiops Hantavirus/classification,immunology Hantavirus Pulmonary Syndrome/blood,immunology,pathology,virology Humans Nucleocapsid Proteins/analysis,immunology Peromyscus Serotyping Vero Cells
Chemicals
Antigens, Viral Nucleocapsid Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Gavrilovskaya I
The Department of Medicine, Stony Brook University, Stony Brook, New York 11794, USA.
LaMonica R
Fay M E
Hjelle B
Schmaljohn C
Shaw R
Mackow E R
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/JCM.37.1.122-126.1999
Published
1999-01-00
Pages
122-6
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC84184
Subset
IM
Grants
NIAID NIH HHS · R01 AI047873 · United States
NIAID NIH HHS · R21 AI080984 · United States
NIAID NIH HHS · R01-AI31016 · United States
NIAID NIH HHS · R03AI42150 · United States
External Links
PubMed source DOI: 10.1128/JCM.37.1.122-126.1999 PMC Full Text View journal details
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