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PMID: 7853545 Published · ppublish English Case Reports Comparative Study Journal Article

A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana.

Journal of virology ·Vol. 69 ·No. 3 ·1995-03-00 ·Pages 1980-3

Morzunov SP, Feldmann H, Spiropoulou CF, Semenova VA, Rollin PE, Ksiazek TG, Peters CJ, Nichol ST

Abstract

Genetic analysis of virus detected in autopsy tissues of a fatal hantavirus pulmonary syndrome-like case in Louisiana revealed the presence of a previously unrecognized hantavirus. Nucleotide sequence analysis of PCR fragments of the complete S and M segments of the virus amplified from RNA extracted from the tissues showed the virus to be novel, differing from the closest related hantavirus, Sin Nombre virus, by approximately 30%. Both genome segments were unique, and there was no evidence of genetic reassortment with previously characterized hantaviruses. The primary rodent reservoir of Sin Nombre virus, the deer mouse Peromyscus maniculatus, is absent from Louisiana. Thus, the virus detected in Louisiana, referred to here as Bayou virus, must possess a different rodent reservoir.

MeSH Terms
Base Sequence DNA Primers/chemistry Hantavirus/genetics,isolation & purification Hantavirus Pulmonary Syndrome/microbiology Humans Louisiana Molecular Sequence Data Phylogeny Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid
Chemicals
DNA Primers
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Morzunov S P
Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
Feldmann H
Spiropoulou C F
Semenova V A
Rollin P E
Ksiazek T G
Peters C J
Nichol S T
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.69.3.1980-1983.1995
Published
1995-03-00
Pages
1980-3
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC188821
Subset
IM
Databases
GENBANK
L36929, L36930
External Links
PubMed source DOI: 10.1128/JVI.69.3.1980-1983.1995 PMC Full Text View journal details
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