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PMID: 984042 Published · ppublish English Journal Article

Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.

American journal of human genetics ·Vol. 28 ·No. 5 ·1976-09-00 ·Pages 465-73

Benn PA

Abstract

In senescent fibroblast cell lines derived from human embryos, the number of chromosome aberrations were found to increase rapidly. In addition to an increase in aneuploidy and polyploidy, a high frequency of dicentrics occurred, but the number of other chromosome abnormalities remained approximately constant. Banding revealed that many of the dicentrics appeared to be end-to-end fusions of whole chromosomes. The involvement of chromosomes was nonrandom. This "telomeric binding" may reflect a progressive decrease in the stability of telomeric sequences or associated enzymes which may also occur in vivo.

MeSH Terms
Cell Line Cell Survival Chromosome Aberrations
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Benn P A
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23 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1976-09-00
Pages
465-73
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685103
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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